IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms14882.html
   My bibliography  Save this article

Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage

Author

Listed:
  • Jesús Mosquera

    (University of Cambridge)

  • Bartosz Szyszko

    (University of Cambridge)

  • Sarah K. Y. Ho

    (University of Cambridge)

  • Jonathan R. Nitschke

    (University of Cambridge)

Abstract

Self-assembly offers a general strategy for the preparation of large, hollow high-symmetry structures. Although biological capsules, such as virus capsids, are capable of selectively recognizing complex cargoes, synthetic encapsulants have lacked the capability to specifically bind large and complex biomolecules. Here we describe a cubic host obtained from the self-assembly of FeII and a zinc-porphyrin-containing ligand. This cubic cage is flexible and compatible with aqueous media. Its selectivity of encapsulation is driven by the coordination of guest functional groups to the zinc porphyrins. This new host thus specifically encapsulates guests incorporating imidazole and thiazole moieties, including drugs and peptides. Once encapsulated, the reactivity of a peptide is dramatically altered: encapsulated peptides are protected from trypsin hydrolysis, whereas physicochemically similar peptides that do not bind are cleaved.

Suggested Citation

  • Jesús Mosquera & Bartosz Szyszko & Sarah K. Y. Ho & Jonathan R. Nitschke, 2017. "Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage," Nature Communications, Nature, vol. 8(1), pages 1-6, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14882
    DOI: 10.1038/ncomms14882
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms14882
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms14882?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yingguo Li & Jialun He & Guilong Lu & Chensheng Wang & Mengmeng Fu & Juan Deng & Fu Yang & Danfeng Jiang & Xiao Chen & Ziyi Yu & Yan Liu & Chao Yu & Yong Cui, 2024. "De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14882. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.