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A persistent prefrontal reference frame across time and task rules

Author

Listed:
  • Hannah Muysers

    (Albert-Ludwigs-University Freiburg
    Albert-Ludwigs-University Freiburg)

  • Hung-Ling Chen

    (Albert-Ludwigs-University Freiburg)

  • Johannes Hahn

    (Goethe University Frankfurt)

  • Shani Folschweiller

    (Albert-Ludwigs-University Freiburg
    Albert-Ludwigs-University Freiburg
    Inselspital, Bern University Hospital, University of Bern)

  • Torfi Sigurdsson

    (Goethe University Frankfurt)

  • Jonas-Frederic Sauer

    (Albert-Ludwigs-University Freiburg)

  • Marlene Bartos

    (Albert-Ludwigs-University Freiburg)

Abstract

Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a ‘core ensemble’ of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time.

Suggested Citation

  • Hannah Muysers & Hung-Ling Chen & Johannes Hahn & Shani Folschweiller & Torfi Sigurdsson & Jonas-Frederic Sauer & Marlene Bartos, 2024. "A persistent prefrontal reference frame across time and task rules," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46350-4
    DOI: 10.1038/s41467-024-46350-4
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    References listed on IDEAS

    as
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