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Genome-wide association studies of brain imaging phenotypes in UK Biobank

Author

Listed:
  • Lloyd T. Elliott

    (University of Oxford)

  • Kevin Sharp

    (University of Oxford)

  • Fidel Alfaro-Almagro

    (University of Oxford)

  • Sinan Shi

    (University of Oxford)

  • Karla L. Miller

    (University of Oxford)

  • Gwenaëlle Douaud

    (University of Oxford)

  • Jonathan Marchini

    (University of Oxford
    University of Oxford)

  • Stephen M. Smith

    (University of Oxford)

Abstract

The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We identify 148 clusters of associations between single nucleotide polymorphisms and imaging phenotypes that replicate at P

Suggested Citation

  • Lloyd T. Elliott & Kevin Sharp & Fidel Alfaro-Almagro & Sinan Shi & Karla L. Miller & Gwenaëlle Douaud & Jonathan Marchini & Stephen M. Smith, 2018. "Genome-wide association studies of brain imaging phenotypes in UK Biobank," Nature, Nature, vol. 562(7726), pages 210-216, October.
    • Handle: RePEc:nat:nature:v:562:y:2018:i:7726:d:10.1038_s41586-018-0571-7
    DOI: 10.1038/s41586-018-0571-7
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    Cited by:

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    2. Benjamin B. Sun & Stephanie J. Loomis & Fabrizio Pizzagalli & Natalia Shatokhina & Jodie N. Painter & Christopher N. Foley & Megan E. Jensen & Donald G. McLaren & Sai Spandana Chintapalli & Alyssa H. , 2022. "Genetic map of regional sulcal morphology in the human brain from UK biobank data," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Weikang Gong & Yan Fu & Bang-Sheng Wu & Jingnan Du & Liu Yang & Ya-Ru Zhang & Shi-Dong Chen & JuJiao Kang & Ying Mao & Qiang Dong & Lan Tan & Jianfeng Feng & Wei Cheng & Jin-Tai Yu, 2024. "Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Juan Lorenzo Rodriguez-Flores & Shareef Khalid & Neelroop Parikshak & Asif Rasheed & Bin Ye & Manav Kapoor & Joshua Backman & Farshid Sepehrband & Silvio Alessandro Di Gioia & Sahar Gelfman & Tanima D, 2024. "NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Junhao Wen & Bingxin Zhao & Zhijian Yang & Guray Erus & Ioanna Skampardoni & Elizabeth Mamourian & Yuhan Cui & Gyujoon Hwang & Jingxuan Bao & Aleix Boquet-Pujadas & Zhen Zhou & Yogasudha Veturi & Mary, 2024. "The genetic architecture of multimodal human brain age," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Zhijian Yang & Junhao Wen & Ahmed Abdulkadir & Yuhan Cui & Guray Erus & Elizabeth Mamourian & Randa Melhem & Dhivya Srinivasan & Sindhuja T. Govindarajan & Jiong Chen & Mohamad Habes & Colin L. Master, 2024. "Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Jordi Manuello & Joosung Min & Paul McCarthy & Fidel Alfaro-Almagro & Soojin Lee & Stephen Smith & Lloyd T. Elliott & Anderson M. Winkler & Gwenaëlle Douaud, 2024. "The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    8. Junjiao Feng & Liang Zhang & Chunhui Chen & Jintao Sheng & Zhifang Ye & Kanyin Feng & Jing Liu & Ying Cai & Bi Zhu & Zhaoxia Yu & Chuansheng Chen & Qi Dong & Gui Xue, 2022. "A cognitive neurogenetic approach to uncovering the structure of executive functions," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    9. Rebecca Shafee & Dustin Moraczewski & Siyuan Liu & Travis Mallard & Adam Thomas & Armin Raznahan, 2024. "A sex-stratified analysis of the genetic architecture of human brain anatomy," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    10. Peter Zhukovsky & Earvin S. Tio & Gillian Coughlan & David A. Bennett & Yanling Wang & Timothy J. Hohman & Diego A. Pizzagalli & Benoit H. Mulsant & Aristotle N. Voineskos & Daniel Felsky, 2024. "Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    11. Chun Chieh Fan & Robert Loughnan & Carolina Makowski & Diliana Pecheva & Chi-Hua Chen & Donald J. Hagler & Wesley K. Thompson & Nadine Parker & Dennis van der Meer & Oleksandr Frei & Ole A. Andreassen, 2022. "Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    12. Michael Wainberg & Natalie J. Forde & Salim Mansour & Isabel Kerrebijn & Sarah E. Medland & Colin Hawco & Shreejoy J. Tripathy, 2024. "Genetic architecture of the structural connectome," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    13. Mengge Liu & Lu Wang & Yujie Zhang & Haoyang Dong & Caihong Wang & Yayuan Chen & Qian Qian & Nannan Zhang & Shaoying Wang & Guoshu Zhao & Zhihui Zhang & Minghuan Lei & Sijia Wang & Qiyu Zhao & Feng Li, 2024. "Investigating the shared genetic architecture between depression and subcortical volumes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    14. Shile Qi & Jing Sui & Godfrey Pearlson & Juan Bustillo & Nora I. Perrone-Bizzozero & Peter Kochunov & Jessica A. Turner & Zening Fu & Wei Shao & Rongtao Jiang & Xiao Yang & Jingyu Liu & Yuhui Du & Jia, 2022. "Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    15. Alan Le Goallec & Samuel Diai & Sasha Collin & Jean-Baptiste Prost & Théo Vincent & Chirag J. Patel, 2022. "Using deep learning to predict abdominal age from liver and pancreas magnetic resonance images," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    16. Tingting Bo & Jie Li & Ganlu Hu & Ge Zhang & Wei Wang & Qian Lv & Shaoling Zhao & Junjie Ma & Meng Qin & Xiaohui Yao & Meiyun Wang & Guang-Zhong Wang & Zheng Wang, 2023. "Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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