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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Author

Listed:
  • Edith Hofer

    (Medical University of Graz
    Medical University of Graz)

  • Gennady V. Roshchupkin

    (Erasmus MC
    Erasmus MC
    Erasmus MC)

  • Hieab H. H. Adams

    (Erasmus MC
    Erasmus MC)

  • Maria J. Knol

    (Erasmus MC)

  • Honghuang Lin

    (Boston University School of Medicine)

  • Shuo Li

    (Boston University School of Public Health)

  • Habil Zare

    (Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio
    The University of Texas Health Science Center)

  • Shahzad Ahmad

    (Erasmus MC)

  • Nicola J. Armstrong

    (Mathematics and Statistics, Murdoch University)

  • Claudia L. Satizabal

    (Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio
    Boston University School of Medicine)

  • Manon Bernard

    (Hospital for Sick Children)

  • Joshua C. Bis

    (University of Washington)

  • Nathan A. Gillespie

    (Virginia Commonwealth University
    QIMR Berghofer Medical Research Institute)

  • Michelle Luciano

    (University of Edinburgh
    University of Edinburgh)

  • Aniket Mishra

    (University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219)

  • Markus Scholz

    (University of Leipzig
    University of Leipzig)

  • Alexander Teumer

    (University Medicine Greifswald)

  • Rui Xia

    (University of Texas Health Science Center at Houston)

  • Xueqiu Jian

    (University of Texas Health Science Center at Houston)

  • Thomas H. Mosley

    (University of Mississippi Medical Center)

  • Yasaman Saba

    (Medical University of Graz)

  • Lukas Pirpamer

    (Medical University of Graz)

  • Stephan Seiler

    (University of California-Davis
    University of California at Davis)

  • James T. Becker

    (University of Pittsburgh)

  • Owen Carmichael

    (Pennington Biomedical Research Center)

  • Jerome I. Rotter

    (Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center)

  • Bruce M. Psaty

    (University of Washington)

  • Oscar L. Lopez

    (University of Pittsburgh)

  • Najaf Amin

    (Erasmus MC)

  • Sven J. Lee

    (Erasmus MC)

  • Qiong Yang

    (Boston University School of Public Health)

  • Jayandra J. Himali

    (Boston University School of Public Health)

  • Pauline Maillard

    (University of California-Davis
    University of California at Davis)

  • Alexa S. Beiser

    (Boston University School of Public Health
    Boston University School of Medicine)

  • Charles DeCarli

    (University of California-Davis
    University of California at Davis)

  • Sherif Karama

    (McGill University, Montreal Neurological Institute)

  • Lindsay Lewis

    (McGill University, Montreal Neurological Institute)

  • Mat Harris

    (University of Edinburgh
    University of Edinburgh
    University of Edinburgh
    The University of Edinburgh)

  • Mark E. Bastin

    (University of Edinburgh
    University of Edinburgh
    University of Edinburgh
    The University of Edinburgh)

  • Ian J. Deary

    (University of Edinburgh
    University of Edinburgh)

  • A. Veronica Witte

    (Max Planck Institute for Human Cognitive and Brain Sciences
    University of Leipzig)

  • Frauke Beyer

    (Max Planck Institute for Human Cognitive and Brain Sciences
    University of Leipzig)

  • Markus Loeffler

    (University of Leipzig
    University of Leipzig)

  • Karen A. Mather

    (University of New South Wales
    Neuroscience Research Australia)

  • Peter R. Schofield

    (Neuroscience Research Australia
    University of New South Wales)

  • Anbupalam Thalamuthu

    (University of New South Wales)

  • John B. Kwok

    (University of New South Wales
    Brain and Mind Centre - The University of Sydney)

  • Margaret J. Wright

    (The University of Queensland
    The University of Queensland)

  • David Ames

    (Royal Melbourne Hospital
    University of Melbourne, St George’s Hospital)

  • Julian Trollor

    (University of New South Wales
    University of New South Wales)

  • Jiyang Jiang

    (University of New South Wales)

  • Henry Brodaty

    (University of New South Wales
    University of New South Wales)

  • Wei Wen

    (University of New South Wales)

  • Meike W. Vernooij

    (Erasmus MC
    Erasmus MC)

  • Albert Hofman

    (Erasmus MC
    Harvard T.H. Chan School of Public Health)

  • André G. Uitterlinden

    (Erasmus MC)

  • Wiro J. Niessen

    (Erasmus MC
    Delft University of Technology)

  • Katharina Wittfeld

    (German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald
    University Medicine Greifswald)

  • Robin Bülow

    (University Medicine Greifswald)

  • Uwe Völker

    (University Medicine Greifswald)

  • Zdenka Pausova

    (Hospital for Sick Children
    University of Toronto)

  • G. Bruce Pike

    (University of Calgary)

  • Sophie Maingault

    (University of Bordeaux)

  • Fabrice Crivello

    (University of Bordeaux)

  • Christophe Tzourio

    (University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219
    Pole de santé publique, Centre Hospitalier Universitaire de Bordeaux)

  • Philippe Amouyel

    (Centre Hospitalier Universitaire de Bordeaux, France; Inserm U1167
    Pasteur Institute of Lille
    Lille University Hospital)

  • Bernard Mazoyer

    (University of Bordeaux)

  • Michael C. Neale

    (Virginia Commonwealth University)

  • Carol E. Franz

    (University of California San Diego)

  • Michael J. Lyons

    (Boston University)

  • Matthew S. Panizzon

    (University of California San Diego)

  • Ole A. Andreassen

    (University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital)

  • Anders M. Dale

    (University of California, San Diego)

  • Mark Logue

    (Boston University School of Public Health
    National Center for PTSD at Boston VA Healthcare System
    Boston University School of Medicine)

  • Katrina L. Grasby

    (Psychiatric Genetics, QIMR Berghofer Medical Research Institute)

  • Neda Jahanshad

    (University of Southern California)

  • Jodie N. Painter

    (Psychiatric Genetics, QIMR Berghofer Medical Research Institute)

  • Lucía Colodro-Conde

    (Psychiatric Genetics, QIMR Berghofer Medical Research Institute)

  • Janita Bralten

    (Radboud university medical center
    Radboud University)

  • Derrek P. Hibar

    (University of Southern California
    Neuroscience Biomarkers, Janssen Research and Development, LLC)

  • Penelope A. Lind

    (Psychiatric Genetics, QIMR Berghofer Medical Research Institute)

  • Fabrizio Pizzagalli

    (University of Southern California)

  • Jason L. Stein

    (University of North Carolina at Chapel Hill)

  • Paul M. Thompson

    (University of Southern California)

  • Sarah E. Medland

    (Psychiatric Genetics, QIMR Berghofer Medical Research Institute)

  • Perminder S. Sachdev

    (University of New South Wales
    Neuropsychiatric Institute, Prince of Wales Hospital)

  • William S. Kremen

    (University of California San Diego)

  • Joanna M. Wardlaw

    (University of Edinburgh
    University of Edinburgh
    University of Edinburgh
    The University of Edinburgh)

  • Arno Villringer

    (Max Planck Institute for Human Cognitive and Brain Sciences
    University Hospital Leipzig)

  • Cornelia M. Duijn

    (Erasmus MC
    University of Oxford)

  • Hans J. Grabe

    (German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald
    University Medicine Greifswald)

  • William T. Longstreth

    (University of Washington)

  • Myriam Fornage

    (University of Texas Health Science Center at Houston)

  • Tomas Paus

    (Holland Bloorview Kids Rehabilitation Hospital
    University of Toronto)

  • Stephanie Debette

    (Boston University School of Medicine
    University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219
    CHU de Bordeaux, Department of Neurology)

  • M. Arfan Ikram

    (Erasmus MC
    Erasmus MC
    Department of Neurology, Erasmus MC)

  • Helena Schmidt

    (Medical University of Graz)

  • Reinhold Schmidt

    (Medical University of Graz)

  • Sudha Seshadri

    (Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio
    Boston University School of Medicine)

Abstract

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

Suggested Citation

  • Edith Hofer & Gennady V. Roshchupkin & Hieab H. H. Adams & Maria J. Knol & Honghuang Lin & Shuo Li & Habil Zare & Shahzad Ahmad & Nicola J. Armstrong & Claudia L. Satizabal & Manon Bernard & Joshua C., 2020. "Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18367-y
    DOI: 10.1038/s41467-020-18367-y
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    Cited by:

    1. Bingxin Zhao & Yujue Li & Zirui Fan & Zhenyi Wu & Juan Shu & Xiaochen Yang & Yilin Yang & Xifeng Wang & Bingxuan Li & Xiyao Wang & Carlos Copana & Yue Yang & Jinjie Lin & Yun Li & Jason L. Stein & Joa, 2024. "Eye-brain connections revealed by multimodal retinal and brain imaging genetics," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Runye Shi & Shitong Xiang & Tianye Jia & Trevor W. Robbins & Jujiao Kang & Tobias Banaschewski & Gareth J. Barker & Arun L. W. Bokde & Sylvane Desrivières & Herta Flor & Antoine Grigis & Hugh Garavan , 2024. "Investigating grey matter volumetric trajectories through the lifespan at the individual level," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Peter Zhukovsky & Earvin S. Tio & Gillian Coughlan & David A. Bennett & Yanling Wang & Timothy J. Hohman & Diego A. Pizzagalli & Benoit H. Mulsant & Aristotle N. Voineskos & Daniel Felsky, 2024. "Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Chun Chieh Fan & Robert Loughnan & Carolina Makowski & Diliana Pecheva & Chi-Hua Chen & Donald J. Hagler & Wesley K. Thompson & Nadine Parker & Dennis van der Meer & Oleksandr Frei & Ole A. Andreassen, 2022. "Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Eva-Maria Stauffer & Richard A. I. Bethlehem & Lena Dorfschmidt & Hyejung Won & Varun Warrier & Edward T. Bullmore, 2023. "The genetic relationships between brain structure and schizophrenia," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Benjamin B. Sun & Stephanie J. Loomis & Fabrizio Pizzagalli & Natalia Shatokhina & Jodie N. Painter & Christopher N. Foley & Megan E. Jensen & Donald G. McLaren & Sai Spandana Chintapalli & Alyssa H. , 2022. "Genetic map of regional sulcal morphology in the human brain from UK biobank data," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    7. Mengge Liu & Lu Wang & Yujie Zhang & Haoyang Dong & Caihong Wang & Yayuan Chen & Qian Qian & Nannan Zhang & Shaoying Wang & Guoshu Zhao & Zhihui Zhang & Minghuan Lei & Sijia Wang & Qiyu Zhao & Feng Li, 2024. "Investigating the shared genetic architecture between depression and subcortical volumes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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