Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals
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DOI: 10.1038/s41467-024-49702-2
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- Clare Bycroft & Colin Freeman & Desislava Petkova & Gavin Band & Lloyd T. Elliott & Kevin Sharp & Allan Motyer & Damjan Vukcevic & Olivier Delaneau & Jared O’Connell & Adrian Cortes & Samantha Welsh &, 2018. "The UK Biobank resource with deep phenotyping and genomic data," Nature, Nature, vol. 562(7726), pages 203-209, October.
- Cristopher V. Van Hout & Ioanna Tachmazidou & Joshua D. Backman & Joshua D. Hoffman & Daren Liu & Ashutosh K. Pandey & Claudia Gonzaga-Jauregui & Shareef Khalid & Bin Ye & Nilanjana Banerjee & Alexand, 2020. "Exome sequencing and characterization of 49,960 individuals in the UK Biobank," Nature, Nature, vol. 586(7831), pages 749-756, October.
- Dorothée Diogo & Chao Tian & Christopher S. Franklin & Mervi Alanne-Kinnunen & Michael March & Chris C. A. Spencer & Ciara Vangjeli & Michael E. Weale & Hannele Mattsson & Elina Kilpeläinen & Patrick , 2018. "Phenome-wide association studies across large population cohorts support drug target validation," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
- Francisco J. Garcia & Na Sun & Hyeseung Lee & Brianna Godlewski & Hansruedi Mathys & Kyriaki Galani & Blake Zhou & Xueqiao Jiang & Ayesha P. Ng & Julio Mantero & Li-Huei Tsai & David A. Bennett & Must, 2022. "Single-cell dissection of the human brain vasculature," Nature, Nature, vol. 603(7903), pages 893-899, March.
- Lloyd T. Elliott & Kevin Sharp & Fidel Alfaro-Almagro & Sinan Shi & Karla L. Miller & Gwenaëlle Douaud & Jonathan Marchini & Stephen M. Smith, 2018. "Genome-wide association studies of brain imaging phenotypes in UK Biobank," Nature, Nature, vol. 562(7726), pages 210-216, October.
- Kyoko Watanabe & Erdogan Taskesen & Arjen Bochoven & Danielle Posthuma, 2017. "Functional mapping and annotation of genetic associations with FUMA," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
- Xueyi Shen & David M. Howard & Mark J. Adams & W. David Hill & Toni-Kim Clarke & Ian J. Deary & Heather C. Whalley & Andrew M. McIntosh, 2020. "A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
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