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Phosphorus deficiency alleviates iron limitation in Synechocystis cyanobacteria through direct PhoB-mediated gene regulation

Author

Listed:
  • Guo-Wei Qiu

    (Central China Normal University)

  • Wen-Can Zheng

    (Central China Normal University)

  • Hao-Ming Yang

    (Central China Normal University)

  • Yu-Ying Wang

    (Central China Normal University)

  • Xing Qi

    (Central China Normal University)

  • Da Huang

    (Central China Normal University)

  • Guo-Zheng Dai

    (Central China Normal University)

  • Huazhong Shi

    (Texas Tech University)

  • Neil M. Price

    (McGill University)

  • Bao-Sheng Qiu

    (Central China Normal University)

Abstract

Iron and phosphorus are essential nutrients that exist at low concentrations in surface waters and may be co-limiting resources for phytoplankton growth. Here, we show that phosphorus deficiency increases the growth of iron-limited cyanobacteria (Synechocystis sp. PCC 6803) through a PhoB-mediated regulatory network. We find that PhoB, in addition to its well-recognized role in controlling phosphate homeostasis, also regulates key metabolic processes crucial for iron-limited cyanobacteria, including ROS detoxification and iron uptake. Transcript abundances of PhoB-targeted genes are enriched in samples from phosphorus-depleted seawater, and a conserved PhoB-binding site is widely present in the promoters of the target genes, suggesting that the PhoB-mediated regulation may be highly conserved. Our findings provide molecular insights into the responses of cyanobacteria to simultaneous iron/phosphorus nutrient limitation.

Suggested Citation

  • Guo-Wei Qiu & Wen-Can Zheng & Hao-Ming Yang & Yu-Ying Wang & Xing Qi & Da Huang & Guo-Zheng Dai & Huazhong Shi & Neil M. Price & Bao-Sheng Qiu, 2024. "Phosphorus deficiency alleviates iron limitation in Synechocystis cyanobacteria through direct PhoB-mediated gene regulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48847-4
    DOI: 10.1038/s41467-024-48847-4
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