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Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer

Author

Listed:
  • Wolfgang Beckabir

    (University of North Carolina at Chapel Hill
    UNC School of Medicine)

  • Mi Zhou

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Jin Seok Lee

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    UNC School of Medicine)

  • Steven P. Vensko

    (University of North Carolina at Chapel Hill)

  • Mark G. Woodcock

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Hsing-Hui Wang

    (University of North Carolina at Chapel Hill
    UNC School of Medicine)

  • Sara E. Wobker

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Gatphan Atassi

    (University of North Carolina at Chapel Hill)

  • Alec D. Wilkinson

    (University of North Carolina at Chapel Hill)

  • Kenneth Fowler

    (University of North Carolina at Chapel Hill)

  • Leah M. Flick

    (University of North Carolina at Chapel Hill)

  • Jeffrey S. Damrauer

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Michael R. Harrison

    (Duke University)

  • Karen P. McKinnon

    (University of North Carolina at Chapel Hill
    UNC School of Medicine)

  • Tracy L. Rose

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Matthew I. Milowsky

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Jonathan S. Serody

    (University of North Carolina at Chapel Hill
    UNC School of Medicine
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • William Y. Kim

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    UNC School of Medicine)

  • Benjamin G. Vincent

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill
    UNC School of Medicine
    University of North Carolina at Chapel Hill)

Abstract

Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in combination with chemotherapy, have demonstrated promising pathologic response (

Suggested Citation

  • Wolfgang Beckabir & Mi Zhou & Jin Seok Lee & Steven P. Vensko & Mark G. Woodcock & Hsing-Hui Wang & Sara E. Wobker & Gatphan Atassi & Alec D. Wilkinson & Kenneth Fowler & Leah M. Flick & Jeffrey S. Da, 2024. "Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48480-1
    DOI: 10.1038/s41467-024-48480-1
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    References listed on IDEAS

    as
    1. Justina X. Caushi & Jiajia Zhang & Zhicheng Ji & Ajay Vaghasia & Boyang Zhang & Emily Han-Chung Hsiue & Brian J. Mog & Wenpin Hou & Sune Justesen & Richard Blosser & Ada Tam & Valsamo Anagnostou & Tri, 2021. "Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers," Nature, Nature, vol. 596(7870), pages 126-132, August.
    2. Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2010. "Regularization Paths for Generalized Linear Models via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 33(i01).
    3. Sanjeev Mariathasan & Shannon J. Turley & Dorothee Nickles & Alessandra Castiglioni & Kobe Yuen & Yulei Wang & Edward E. Kadel III & Hartmut Koeppen & Jillian L. Astarita & Rafael Cubas & Suchit Jhunj, 2018. "TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells," Nature, Nature, vol. 554(7693), pages 544-548, February.
    4. Romain Banchereau & Ning Leng & Oliver Zill & Ethan Sokol & Gengbo Liu & Dean Pavlick & Sophia Maund & Li-Fen Liu & Edward Kadel & Nicole Baldwin & Suchit Jhunjhunwala & Dorothee Nickles & Zoe June As, 2021. "Molecular determinants of response to PD-L1 blockade across tumor types," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    5. Jeffrey S. Damrauer & Wolfgang Beckabir & Jeff Klomp & Mi Zhou & Elizabeth R. Plimack & Matthew D. Galsky & Petros Grivas & Noah M. Hahn & Peter H. O’Donnell & Gopa Iyer & David I. Quinn & Benjamin G., 2022. "Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Justina X. Caushi & Jiajia Zhang & Zhicheng Ji & Ajay Vaghasia & Boyang Zhang & Emily Han-Chung Hsiue & Brian J. Mog & Wenpin Hou & Sune Justesen & Richard Blosser & Ada Tam & Valsamo Anagnostou & Tri, 2021. "Author Correction: Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers," Nature, Nature, vol. 598(7881), pages 1-1, October.
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