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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Author

Listed:
  • Sanjeev Mariathasan

    (Genentech, South San Francisco)

  • Shannon J. Turley

    (Genentech, South San Francisco)

  • Dorothee Nickles

    (Genentech, South San Francisco)

  • Alessandra Castiglioni

    (Genentech, South San Francisco)

  • Kobe Yuen

    (Genentech, South San Francisco)

  • Yulei Wang

    (Genentech, South San Francisco)

  • Edward E. Kadel III

    (Genentech, South San Francisco)

  • Hartmut Koeppen

    (Genentech, South San Francisco)

  • Jillian L. Astarita

    (Genentech, South San Francisco)

  • Rafael Cubas

    (Genentech, South San Francisco)

  • Suchit Jhunjhunwala

    (Genentech, South San Francisco)

  • Romain Banchereau

    (Genentech, South San Francisco)

  • Yagai Yang

    (Genentech, South San Francisco)

  • Yinghui Guan

    (Genentech, South San Francisco)

  • Cecile Chalouni

    (Genentech, South San Francisco)

  • James Ziai

    (Genentech, South San Francisco)

  • Yasin Şenbabaoğlu

    (Genentech, South San Francisco)

  • Stephen Santoro

    (Genentech, South San Francisco)

  • Daniel Sheinson

    (Genentech, South San Francisco)

  • Jeffrey Hung

    (Genentech, South San Francisco)

  • Jennifer M. Giltnane

    (Genentech, South San Francisco)

  • Andrew A. Pierce

    (Genentech, South San Francisco)

  • Kathryn Mesh

    (Genentech, South San Francisco)

  • Steve Lianoglou

    (Genentech, South San Francisco)

  • Johannes Riegler

    (Genentech, South San Francisco)

  • Richard A. D. Carano

    (Genentech, South San Francisco)

  • Pontus Eriksson

    (Lund University)

  • Mattias Höglund

    (Lund University)

  • Loan Somarriba

    (Fios Genomics)

  • Daniel L. Halligan

    (Fios Genomics)

  • Michiel S. van der Heijden

    (Netherlands Cancer Institute)

  • Yohann Loriot

    (Institut Gustave Roussy, University of Paris Sud)

  • Jonathan E. Rosenberg

    (Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center)

  • Lawrence Fong

    (University of California San Francisco, Helen Diller Family Comprehensive Cancer Center)

  • Ira Mellman

    (Genentech, South San Francisco)

  • Daniel S. Chen

    (Genentech, South San Francisco)

  • Marjorie Green

    (Genentech, South San Francisco)

  • Christina Derleth

    (Genentech, South San Francisco)

  • Gregg D. Fine

    (Genentech, South San Francisco)

  • Priti S. Hegde

    (Genentech, South San Francisco)

  • Richard Bourgon

    (Genentech, South San Francisco)

  • Thomas Powles

    (Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London)

Abstract

In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

Suggested Citation

  • Sanjeev Mariathasan & Shannon J. Turley & Dorothee Nickles & Alessandra Castiglioni & Kobe Yuen & Yulei Wang & Edward E. Kadel III & Hartmut Koeppen & Jillian L. Astarita & Rafael Cubas & Suchit Jhunj, 2018. "TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells," Nature, Nature, vol. 554(7693), pages 544-548, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25501
    DOI: 10.1038/nature25501
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