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Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents

Author

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  • Mengting Liao

    (Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
    National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China
    Health Management Center, Xiangya Hospital, Central South University, Changsha 410008, China
    These authors contributed equally to this work.)

  • Yi Xiao

    (Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
    National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China
    These authors contributed equally to this work.)

  • Shenxin Li

    (Department of Surveying and Remote Sensing Science, School of Geosciences and Info-Physics, Central South University, Changsha 410008, China)

  • Juan Su

    (Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China)

  • Ji Li

    (Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China)

  • Bin Zou

    (Department of Surveying and Remote Sensing Science, School of Geosciences and Info-Physics, Central South University, Changsha 410008, China)

  • Xiang Chen

    (Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
    National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China
    National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha 410008, China)

  • Minxue Shen

    (Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
    Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410008, China)

Abstract

Atopic dermatitis (AD), chronic hand eczema (CHE), and urticaria are common inflammatory skin diseases among adolescents and associated with air quality. However, the synergistic effects of ambient air pollution and second-hand smoke (SHS) have been unclear. We conducted a cross-sectional study including 20,138 Chinese college students where dermatological examinations and a questionnaire survey were carried out. A generalized linear mixed model was applied for the association between individualized exposure of O 3 , CO, NO 2 , SO 2 , PM 2.5 , and PM 10 and the prevalence of inflammatory skin diseases. Interactions between air pollutants and SHS were analyzed. As a result, CO, NO 2 , SO 2 , PM 2.5 , and PM 10 were positively correlated with the prevalence of AD, CHE, and urticaria. Higher frequency of SHS exposure contributed to increased probabilities of AD ( p = 0.042), CHE ( p < 0.001), and urticaria ( p = 0.002). Of note, CO (OR: 2.57 (1.16–5.69) in third quartile) and NO 2 (OR: 2.38 (1.07–5.27) in third quartile) had positive interactions with SHS for AD, and PM 2.5 synergized with SHS for CHE (OR: 2.25 (1.22–4.15) for second quartile). Subgroup analyses agreed with the synergistic results. In conclusion, SHS and ambient air pollution are both associated with inflammatory skin diseases, and they have a synergistic effect on the prevalence of AD and CHE.

Suggested Citation

  • Mengting Liao & Yi Xiao & Shenxin Li & Juan Su & Ji Li & Bin Zou & Xiang Chen & Minxue Shen, 2022. "Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents," IJERPH, MDPI, vol. 19(16), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10011-:d:887692
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    References listed on IDEAS

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