IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v500y2013i7461d10.1038_nature12331.html
   My bibliography  Save this article

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Author

Listed:
  • Koji Atarashi

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan)

  • Takeshi Tanoue

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Kenshiro Oshima

    (CREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan
    Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan)

  • Wataru Suda

    (Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan)

  • Yuji Nagano

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Hiroyoshi Nishikawa

    (Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Shinji Fukuda

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Tsuruoka, Yamagata 997-0052, Japan)

  • Takuro Saito

    (Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Seiko Narushima

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Koji Hase

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan)

  • Sangwan Kim

    (Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan)

  • Joëlle V. Fritz

    (Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Avenue des Hauts-Fourneaux, 7, Esch-sur-Alzette, L-4362, Luxembourg)

  • Paul Wilmes

    (Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Avenue des Hauts-Fourneaux, 7, Esch-sur-Alzette, L-4362, Luxembourg)

  • Satoshi Ueha

    (Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Kouji Matsushima

    (Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Hiroshi Ohno

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Bernat Olle

    (PureTech Ventures, 500 Boylston Street, Suite 1600, Boston, Massachusetts 02116, USA)

  • Shimon Sakaguchi

    (Experimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Tadatsugu Taniguchi

    (Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Hidetoshi Morita

    (CREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan
    School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 252-5201, Japan)

  • Masahira Hattori

    (Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan)

  • Kenya Honda

    (RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    CREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan)

Abstract

This study identifies 17 strains of human-derived Clostridia capable of inducing the accumulation and functional maturation of regulatory T cells; it is suggested that these strains may be useful candidates for the future development of oral bacterial therapeutics to treat human inflammatory disorders.

Suggested Citation

  • Koji Atarashi & Takeshi Tanoue & Kenshiro Oshima & Wataru Suda & Yuji Nagano & Hiroyoshi Nishikawa & Shinji Fukuda & Takuro Saito & Seiko Narushima & Koji Hase & Sangwan Kim & Joëlle V. Fritz & Paul W, 2013. "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota," Nature, Nature, vol. 500(7461), pages 232-236, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12331
    DOI: 10.1038/nature12331
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12331
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12331?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kazumichi Abe & Atsushi Takahashi & Masashi Fujita & Hiromichi Imaizumi & Manabu Hayashi & Ken Okai & Hiromasa Ohira, 2018. "Dysbiosis of oral microbiota and its association with salivary immunological biomarkers in autoimmune liver disease," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-19, July.
    2. Nguyen T. Van & Karen Zhang & Rachel M. Wigmore & Anne I. Kennedy & Carolina R. DaSilva & Jialing Huang & Manju Ambelil & Jose H. Villagomez & Gerald J. O’Connor & Randy S. Longman & Miao Cao & Adam E, 2023. "Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Antonella Gagliardi & Valentina Totino & Fatima Cacciotti & Valerio Iebba & Bruna Neroni & Giulia Bonfiglio & Maria Trancassini & Claudio Passariello & Fabrizio Pantanella & Serena Schippa, 2018. "Rebuilding the Gut Microbiota Ecosystem," IJERPH, MDPI, vol. 15(8), pages 1-24, August.
    4. Lizhen Zhu & Geng Li & Zhixin Liang & Tuan Qi & Kui Deng & Jiancheng Yu & Yue Peng & Jusheng Zheng & Yan Song & Xing Chang, 2023. "Microbiota-assisted iron uptake promotes immune tolerance in the intestine," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Mengting Liao & Yi Xiao & Shenxin Li & Juan Su & Ji Li & Bin Zou & Xiang Chen & Minxue Shen, 2022. "Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents," IJERPH, MDPI, vol. 19(16), pages 1-12, August.
    6. Alice Risely & Kerstin Wilhelm & Tim Clutton-Brock & Marta B. Manser & Simone Sommer, 2021. "Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    7. Arihiro Shiozaki & Satoshi Yoneda & Noriko Yoneda & Rika Yonezawa & Takamichi Matsubayashi & Genichiro Seo & Shigeru Saito, 2014. "Intestinal Microbiota is Different in Women with Preterm Birth: Results from Terminal Restriction Fragment Length Polymorphism Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-1, November.
    8. Alex E. Mohr & Karen L. Sweazea & Devin A. Bowes & Paniz Jasbi & Corrie M. Whisner & Dorothy D. Sears & Rosa Krajmalnik-Brown & Yan Jin & Haiwei Gu & Judith Klein-Seetharaman & Karen M. Arciero & Eric, 2024. "Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    9. Ondrej Suchanek & John R. Ferdinand & Zewen K. Tuong & Sathi Wijeyesinghe & Anita Chandra & Ann-Katrin Clauder & Larissa N. Almeida & Simon Clare & Katherine Harcourt & Christopher J. Ward & Rachael B, 2023. "Tissue-resident B cells orchestrate macrophage polarisation and function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:500:y:2013:i:7461:d:10.1038_nature12331. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.