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Diversity, stability and resilience of the human gut microbiota

Author

Listed:
  • Catherine A. Lozupone

    (University of Colorado)

  • Jesse I. Stombaugh

    (University of Colorado)

  • Jeffrey I. Gordon

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Janet K. Jansson

    (Lawrence Berkeley National Laboratory
    Joint Genome Institute, Lawrence Berkeley National Laboratory)

  • Rob Knight

    (University of Colorado
    Howard Hughes Medical Institute
    Biofrontiers Institute, University of Colorado)

Abstract

Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions. Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that target it. This goal is formidable. The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time — especially during disease and early development. Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments.

Suggested Citation

  • Catherine A. Lozupone & Jesse I. Stombaugh & Jeffrey I. Gordon & Janet K. Jansson & Rob Knight, 2012. "Diversity, stability and resilience of the human gut microbiota," Nature, Nature, vol. 489(7415), pages 220-230, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11550
    DOI: 10.1038/nature11550
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