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Lifecycle of a predatory bacterium vampirizing its prey through the cell envelope and S-layer

Author

Listed:
  • Yoann G. Santin

    (UCLouvain)

  • Adrià Sogues

    (Structural Biology Research Center, VIB
    Vrije Universiteit Brussel)

  • Yvann Bourigault

    (UCLouvain)

  • Han K. Remaut

    (Structural Biology Research Center, VIB
    Vrije Universiteit Brussel)

  • Géraldine Laloux

    (UCLouvain)

Abstract

Predatory bacteria feed upon other bacteria in various environments. Bdellovibrio exovorus is an obligate epibiotic predator that attaches on the prey cell surface, where it grows and proliferates. Although the mechanisms allowing feeding through the prey cell envelope are unknown, it has been proposed that the prey’s proteinaceous S-layer may act as a defensive structure against predation. Here, we use time-lapse and cryo-electron microscopy to image the lifecycle of B. exovorus feeding on Caulobacter crescentus. We show that B. exovorus proliferates by non-binary division, primarily generating three daughter cells. Moreover, the predator feeds on C. crescentus regardless of the presence of an S-layer, challenging its assumed protective role against predators. Finally, we show that apparently secure junctions are established between prey and predator outer membranes.

Suggested Citation

  • Yoann G. Santin & Adrià Sogues & Yvann Bourigault & Han K. Remaut & Géraldine Laloux, 2024. "Lifecycle of a predatory bacterium vampirizing its prey through the cell envelope and S-layer," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48042-5
    DOI: 10.1038/s41467-024-48042-5
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    References listed on IDEAS

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    1. Hannah G. Hampton & Bridget N. J. Watson & Peter C. Fineran, 2020. "The arms race between bacteria and their phage foes," Nature, Nature, vol. 577(7790), pages 327-336, January.
    2. Sara Rombouts & Anna Mas & Antoine Gall & Jean-Bernard Fiche & Tâm Mignot & Marcelo Nollmann, 2023. "Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
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