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Multiplicative joint coding in preparatory activity for reaching sequence in macaque motor cortex

Author

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  • Tianwei Wang

    (Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Institute for Brain Research)

  • Yun Chen

    (Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Institute for Brain Research)

  • Yiheng Zhang

    (Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Institute for Brain Research)

  • He Cui

    (Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Institute for Brain Research
    Shanghai Center for Brain Science and Brain-inspired Technology)

Abstract

Although the motor cortex has been found to be modulated by sensory or cognitive sequences, the linkage between multiple movement elements and sequence-related responses is not yet understood. Here, we recorded neuronal activity from the motor cortex with implanted micro-electrode arrays and single electrodes while monkeys performed a double-reach task that was instructed by simultaneously presented memorized cues. We found that there existed a substantial multiplicative component jointly tuned to impending and subsequent reaches during preparation, then the coding mechanism transferred to an additive manner during execution. This multiplicative joint coding, which also spontaneously emerged in recurrent neural networks trained for double reach, enriches neural patterns for sequential movement, and might explain the linear readout of elemental movements.

Suggested Citation

  • Tianwei Wang & Yun Chen & Yiheng Zhang & He Cui, 2024. "Multiplicative joint coding in preparatory activity for reaching sequence in macaque motor cortex," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47511-1
    DOI: 10.1038/s41467-024-47511-1
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    References listed on IDEAS

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