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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

Author

Listed:
  • Jinghe Huang

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Byong H. Kang

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Marie Pancera

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Jeong Hyun Lee

    (The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • Tommy Tong

    (San Diego Biomedical Research Institute)

  • Yu Feng

    (International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • Hiromi Imamichi

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Ivelin S. Georgiev

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Gwo-Yu Chuang

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Aliaksandr Druz

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Nicole A. Doria-Rose

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Leo Laub

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Kwinten Sliepen

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Marit J. van Gils

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Alba Torrents de la Peña

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Ronald Derking

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Per-Johan Klasse

    (Weill Medical College of Cornell University)

  • Stephen A. Migueles

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Robert T. Bailer

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Munir Alam

    (Duke Human Vaccine Institute, Duke University)

  • Pavel Pugach

    (Weill Medical College of Cornell University)

  • Barton F. Haynes

    (Duke Human Vaccine Institute, Duke University)

  • Richard T. Wyatt

    (The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • Rogier W. Sanders

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
    Weill Medical College of Cornell University)

  • James M. Binley

    (San Diego Biomedical Research Institute)

  • Andrew B. Ward

    (The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • John R. Mascola

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Peter D. Kwong

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Mark Connors

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Molecular and structural characterization is reported for a new broad and potent monoclonal antibody against HIV that binds to an epitope bridging the gp41 and gp120 subunits — the antibody affects a step in virus entry after binding to CD4 and before engagement of CCR5.

Suggested Citation

  • Jinghe Huang & Byong H. Kang & Marie Pancera & Jeong Hyun Lee & Tommy Tong & Yu Feng & Hiromi Imamichi & Ivelin S. Georgiev & Gwo-Yu Chuang & Aliaksandr Druz & Nicole A. Doria-Rose & Leo Laub & Kwinte, 2014. "Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface," Nature, Nature, vol. 515(7525), pages 138-142, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13601
    DOI: 10.1038/nature13601
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    Citations

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    Cited by:

    1. Kun-Wei Chan & Christina C. Luo & Hong Lu & Xueling Wu & Xiang-Peng Kong, 2021. "A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Annemart Koornneef & Kanika Vanshylla & Gijs Hardenberg & Lucy Rutten & Nika M. Strokappe & Jeroen Tolboom & Jessica Vreugdenhil & Karin Feddes-de Boer & Aditya Perkasa & Sven Blokland & Judith A. Bur, 2024. "CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Jun Niu & Qi Wang & Wenwen Zhao & Bing Meng & Youwei Xu & Xianfang Zhang & Yi Feng & Qilian Qi & Yanling Hao & Xuan Zhang & Ying Liu & Jiangchao Xiang & Yiming Shao & Bei Yang, 2023. "Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Yi-Nan Zhang & Jennifer Paynter & Aleksandar Antanasijevic & Joel D. Allen & Mor Eldad & Yi-Zong Lee & Jeffrey Copps & Maddy L. Newby & Linling He & Deborah Chavez & Pat Frost & Anna Goodroe & John Du, 2023. "Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates," Nature Communications, Nature, vol. 14(1), pages 1-29, December.

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