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A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

Author

Listed:
  • Rajeev Gautam

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Yoshiaki Nishimura

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Amarendra Pegu

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Martha C. Nason

    (Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Florian Klein

    (Laboratory of Molecular Immunology, The Rockefeller University
    Laboratory of Experimental Immunology, Center for Molecular Medicine Cologne (CMMC), University of Cologne
    Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne)

  • Anna Gazumyan

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Jovana Golijanin

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Alicia Buckler-White

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Reza Sadjadpour

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Keyun Wang

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Zachary Mankoff

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Stephen D. Schmidt

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research)

  • John R. Mascola

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute)

  • Malcolm A. Martin

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

A single injection of four anti-HIV-1-neutralizing monoclonal antibodies blocks repeated weekly low-dose virus challenges of simian/human immunodeficiency virus.

Suggested Citation

  • Rajeev Gautam & Yoshiaki Nishimura & Amarendra Pegu & Martha C. Nason & Florian Klein & Anna Gazumyan & Jovana Golijanin & Alicia Buckler-White & Reza Sadjadpour & Keyun Wang & Zachary Mankoff & Steph, 2016. "A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges," Nature, Nature, vol. 533(7601), pages 105-109, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7601:d:10.1038_nature17677
    DOI: 10.1038/nature17677
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    Cited by:

    1. Mathilde Foglierini & Pauline Nortier & Rachel Schelling & Rahel R. Winiger & Philippe Jacquet & Sijy O’Dell & Davide Demurtas & Maxmillian Mpina & Omar Lweno & Yannick D. Muller & Constantinos Petrov, 2024. "RAIN: machine learning-based identification for HIV-1 bNAbs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Annemart Koornneef & Kanika Vanshylla & Gijs Hardenberg & Lucy Rutten & Nika M. Strokappe & Jeroen Tolboom & Jessica Vreugdenhil & Karin Feddes-de Boer & Aditya Perkasa & Sven Blokland & Judith A. Bur, 2024. "CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Christoph Kreer & Cosimo Lupo & Meryem S. Ercanoglu & Lutz Gieselmann & Natanael Spisak & Jan Grossbach & Maike Schlotz & Philipp Schommers & Henning Gruell & Leona Dold & Andreas Beyer & Armita Nourm, 2023. "Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Jérémy Dufloo & Cyril Planchais & Stéphane Frémont & Valérie Lorin & Florence Guivel-Benhassine & Karl Stefic & Nicoletta Casartelli & Arnaud Echard & Philippe Roingeard & Hugo Mouquet & Olivier Schwa, 2022. "Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Karunasinee Suphaphiphat & Delphine Desjardins & Valérie Lorin & Nastasia Dimant & Kawthar Bouchemal & Laetitia Bossevot & Maxence Galpin-Lebreau & Nathalie Dereuddre-Bosquet & Hugo Mouquet & Roger Gr, 2023. "Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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