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Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs

Author

Listed:
  • Calvin H. Jan

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology)

  • Robin C. Friedman

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology
    Computational and Systems Biology Program, Massachusetts Institute of Technology)

  • J. Graham Ruby

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology
    Present address: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, USA (J.G.R.).)

  • David P. Bartel

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology)

Abstract

Cleaning up the transcriptome When genes are transcribed into RNA, the polymerase extends beyond the protein-coding portion to make the 3′ untranslated region (UTR), which contains regulatory sequences and facilitates translation. Long tracts of adenine are added to the 3′ UTR, and the standard method for sequencing the transcriptome is based on hybridization to the poly(A) tail. Jan et al. report a new high-throughput approach to transcriptome sequencing that avoids the limitations of the poly(A) method, and use the new technique to provide a more accurate analysis of 3′ UTRs in the roundworm.

Suggested Citation

  • Calvin H. Jan & Robin C. Friedman & J. Graham Ruby & David P. Bartel, 2011. "Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs," Nature, Nature, vol. 469(7328), pages 97-101, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7328:d:10.1038_nature09616
    DOI: 10.1038/nature09616
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    Cited by:

    1. Xueqing Wang & Quanlong Jiang & Hongdao Zhang & Zhidong He & Yuanyuan Song & Yifan Chen & Na Tang & Yifei Zhou & Yiping Li & Adam Antebi & Ligang Wu & Jing-Dong J. Han & Yidong Shen, 2024. "Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Weina Xu & Jinyi Liu & Huan Qi & Ruolin Si & Zhiguang Zhao & Zhiju Tao & Yuchuan Bai & Shipeng Hu & Xiaohan Sun & Yulin Cong & Haoye Zhang & Duchangjiang Fan & Long Xiao & Yangyang Wang & Yongbin Li &, 2024. "A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    3. Seungjae Lee & Yen-Chung Chen & Austin E. Gillen & J. Matthew Taliaferro & Bart Deplancke & Hongjie Li & Eric C. Lai, 2022. "Diverse cell-specific patterns of alternative polyadenylation in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Carlos A. Vergani-Junior & Raíssa De P. Moro & Silas Pinto & Evandro A. De-Souza & Henrique Camara & Deisi L. Braga & Guilherme Tonon-da-Silva & Thiago L. Knittel & Gabriel P. Ruiz & Raissa G. Ludwig , 2024. "An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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