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The genetics of ageing

Author

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  • Cynthia J. Kenyon

    (University of California, San Francisco)

Abstract

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that over evolutionary time mutations have increased lifespan more than 2,000-fold. Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions.

Suggested Citation

  • Cynthia J. Kenyon, 2010. "The genetics of ageing," Nature, Nature, vol. 464(7288), pages 504-512, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7288:d:10.1038_nature08980
    DOI: 10.1038/nature08980
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    Cited by:

    1. Caroline Beaudoin-Chabot & Lei Wang & Cenk Celik & Aishah Tul-Firdaus Abdul Khalid & Subhash Thalappilly & Shiyi Xu & Jhee Hong Koh & Venus Wen Xuan Lim & Ann Don Low & Guillaume Thibault, 2022. "The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Yan-Ping Zhang & Wen-Hong Zhang & Pan Zhang & Qi Li & Yue Sun & Jia-Wen Wang & Shaobing O. Zhang & Tao Cai & Cheng Zhan & Meng-Qiu Dong, 2022. "Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Mark G Sterken & L Basten Snoek & Kobus J Bosman & Jikke Daamen & Joost A G Riksen & Jaap Bakker & Gorben P Pijlman & Jan E Kammenga, 2014. "A Heritable Antiviral RNAi Response Limits Orsay Virus Infection in Caenorhabditis elegans N2," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    4. Huiru Bai & Xiaoqin Liu & Meizhen Lin & Yuan Meng & Ruolan Tang & Yajing Guo & Nan Li & Michael F. Clarke & Shang Cai, 2024. "Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Jin-Hyuck Jeong & Jun-Seok Han & Youngae Jung & Seung-Min Lee & So-Hyun Park & Mooncheol Park & Min-Gi Shin & Nami Kim & Mi Sun Kang & Seokho Kim & Kwang-Pyo Lee & Ki-Sun Kwon & Chun-A. Kim & Yong Ryo, 2023. "A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Ádám Sturm & Éva Saskői & Bernadette Hotzi & Anna Tarnóci & János Barna & Ferenc Bodnár & Himani Sharma & Tibor Kovács & Eszter Ari & Nóra Weinhardt & Csaba Kerepesi & András Perczel & Zoltán Ivics & , 2023. "Downregulation of transposable elements extends lifespan in Caenorhabditis elegans," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Edouard Debonneuil & Anne Eyraud-Loisel & Frédéric Planchet, 2018. "Can Pension Funds Partially Manage Longevity Risk by Investing in a Longevity Megafund?," Risks, MDPI, vol. 6(3), pages 1-27, July.
    8. Qucheng Deng & Lijuan Chen & Yongping Wei & Yonghua Li & Xuerong Han & Wei Liang & Yinjun Zhao & Xiaofei Wang & Juan Yin, 2018. "Understanding the Association between Environmental Factors and Longevity in Hechi, China: A Drinking Water and Soil Quality Perspective," IJERPH, MDPI, vol. 15(10), pages 1-17, October.
    9. Smith, Ken R. & Hanson, Heidi A. & Norton, Maria C. & Hollingshaus, Michael S. & Mineau, Geraldine P., 2014. "Survival of offspring who experience early parental death: Early life conditions and later-life mortality," Social Science & Medicine, Elsevier, vol. 119(C), pages 180-190.
    10. Zhifei Zhang & Haiyan Yang & Lei Fang & Guangrong Zhao & Jun Xiang & Jialin C. Zheng & Zhao Qin, 2024. "DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    11. Jiangbo Song & Zhiquan Li & Lei Zhou & Xin Chen & Wei Qi Guinevere Sew & Héctor Herranz & Zilu Ye & Jesper Velgaard Olsen & Yuan Li & Marianne Nygaard & Kaare Christensen & Xiaoling Tong & Vilhelm A. , 2024. "FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    12. Qucheng Deng & Yongping Wei & Lijuan Chen & Wei Liang & Jijun Du & Yuling Tan & Yinjun Zhao, 2019. "Relationship between Air Pollution and Regional Longevity in Guangxi, China," IJERPH, MDPI, vol. 16(19), pages 1-12, October.
    13. Xueqing Wang & Quanlong Jiang & Hongdao Zhang & Zhidong He & Yuanyuan Song & Yifan Chen & Na Tang & Yifei Zhou & Yiping Li & Adam Antebi & Ligang Wu & Jing-Dong J. Han & Yidong Shen, 2024. "Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    14. Arles Urrutia & Víctor A García-Angulo & Andrés Fuentes & Mauricio Caneo & Marcela Legüe & Sebastián Urquiza & Scarlett E Delgado & Juan Ugalde & Paula Burdisso & Andrea Calixto, 2020. "Bacterially produced metabolites protect C. elegans neurons from degeneration," PLOS Biology, Public Library of Science, vol. 18(3), pages 1-31, March.
    15. Paul R. H. J. Timmers & James F. Wilson & Peter K. Joshi & Joris Deelen, 2020. "Multivariate genomic scan implicates novel loci and haem metabolism in human ageing," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    16. Daniele Campa & Francesco De Rango & Maura Carrai & Paolina Crocco & Alberto Montesanto & Federico Canzian & Giuseppina Rose & Cosmeri Rizzato & Giuseppe Passarino & Roberto Barale, 2012. "Bitter Taste Receptor Polymorphisms and Human Aging," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-8, November.
    17. Kejun Ying & José P. Castro & Anastasia V. Shindyapina & Alexander Tyshkovskiy & Mahdi Moqri & Ludger J. E. Goeminne & Sofiya Milman & Zhengdong D. Zhang & Nir Barzilai & Vadim N. Gladyshev, 2024. "Depletion of loss-of-function germline mutations in centenarians reveals longevity genes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    18. Carlos A. Vergani-Junior & Raíssa De P. Moro & Silas Pinto & Evandro A. De-Souza & Henrique Camara & Deisi L. Braga & Guilherme Tonon-da-Silva & Thiago L. Knittel & Gabriel P. Ruiz & Raissa G. Ludwig , 2024. "An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    19. Céline N Martineau & André E X Brown & Patrick Laurent, 2020. "Multidimensional phenotyping predicts lifespan and quantifies health in Caenorhabditis elegans," PLOS Computational Biology, Public Library of Science, vol. 16(7), pages 1-14, July.
    20. Harper S. Kim & Danitra J. Parker & Madison M. Hardiman & Erin Munkácsy & Nisi Jiang & Aric N. Rogers & Yidong Bai & Colin Brent & James A. Mobley & Steven N. Austad & Andrew M. Pickering, 2023. "Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    21. Eirini Lionaki & Ilias Gkikas & Ioanna Daskalaki & Maria-Konstantina Ioannidi & Maria I. Klapa & Nektarios Tavernarakis, 2022. "Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    22. Cyril Statzer & Jin Meng & Richard Venz & Monet Bland & Stacey Robida-Stubbs & Krina Patel & Dunja Petrovic & Raffaella Emsley & Pengpeng Liu & Ianessa Morantte & Cole Haynes & William B. Mair & Alban, 2022. "ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    23. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.

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