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Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans

Author

Listed:
  • Xueqing Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Quanlong Jiang

    (Chinese Academy of Sciences
    Peking University)

  • Hongdao Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhidong He

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yuanyuan Song

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yifan Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Na Tang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yifei Zhou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yiping Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Adam Antebi

    (Max Planck Institute for Biology of Ageing
    University of Cologne)

  • Ligang Wu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jing-Dong J. Han

    (Peking University)

  • Yidong Shen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messengers. However, little is known about the tissue-specific transcriptomic changes of miRNAs during ageing. C. elegans is a well-established model organism in ageing research. Here, we profile the age-dependent miRNAomic changes in five isolated worm tissues. Besides the diverse ageing-regulated miRNA expression across tissues, we discover numerous miRNAs in the tissues without their transcription. We further profile miRNAs in the extracellular vesicles and find that worm miRNAs undergo inter-tissue trafficking via these vesicles in an age-dependent manner. Using these datasets, we uncover the interaction between body wall muscle-derived mir-1 and DAF-16/FOXO in the intestine, suggesting mir-1 as a messenger in inter-tissue signalling. Taken together, we systematically investigate worm miRNAs in the somatic tissues and extracellular vesicles during ageing, providing a valuable resource to study tissue-autonomous and nonautonomous functions of miRNAs in ageing.

Suggested Citation

  • Xueqing Wang & Quanlong Jiang & Hongdao Zhang & Zhidong He & Yuanyuan Song & Yifan Chen & Na Tang & Yifei Zhou & Yiping Li & Adam Antebi & Ligang Wu & Jing-Dong J. Han & Yidong Shen, 2024. "Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45249-4
    DOI: 10.1038/s41467-024-45249-4
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    References listed on IDEAS

    as
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