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Bitter Taste Receptor Polymorphisms and Human Aging

Author

Listed:
  • Daniele Campa
  • Francesco De Rango
  • Maura Carrai
  • Paolina Crocco
  • Alberto Montesanto
  • Federico Canzian
  • Giuseppina Rose
  • Cosmeri Rizzato
  • Giuseppe Passarino
  • Roberto Barale

Abstract

Several studies have shown that genetic factors account for 25% of the variation in human life span. On the basis of published molecular, genetic and epidemiological data, we hypothesized that genetic polymorphisms of taste receptors, which modulate food preferences but are also expressed in a number of organs and regulate food absorption processing and metabolism, could modulate the aging process. Using a tagging approach, we investigated the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 individuals ranging in age from 20 to 106 years from the South of Italy. We found that one polymorphism, rs978739, situated 212 bp upstream of the TAS2R16 gene, shows a statistically significant association (p = 0.001) with longevity. In particular, the frequency of A/A homozygotes increases gradually from 35% in subjects aged 20 to 70 up to 55% in centenarians. These data provide suggestive evidence on the possible correlation between human longevity and taste genetics.

Suggested Citation

  • Daniele Campa & Francesco De Rango & Maura Carrai & Paolina Crocco & Alberto Montesanto & Federico Canzian & Giuseppina Rose & Cosmeri Rizzato & Giuseppe Passarino & Roberto Barale, 2012. "Bitter Taste Receptor Polymorphisms and Human Aging," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0045232
    DOI: 10.1371/journal.pone.0045232
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    References listed on IDEAS

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    1. Cynthia J. Kenyon, 2010. "The genetics of ageing," Nature, Nature, vol. 464(7288), pages 504-512, March.
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    1. Hasna Amir Mohaus, 2019. "Dental Caries among Tasters and Non-Tasters of PTC Substance in Students of Qurna Population," Journal of Molecular Biology Research, Canadian Center of Science and Education, vol. 9(1), pages 1-82, December.

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