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Parallel processing of working memory and temporal information by distinct types of cortical projection neurons

Author

Listed:
  • Jung Won Bae

    (Korea Advanced Institute of Science and Technology)

  • Huijeong Jeong

    (Korea Advanced Institute of Science and Technology
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

  • Young Ju Yoon

    (Korea Advanced Institute of Science and Technology)

  • Chan Mee Bae

    (Korea Advanced Institute of Science and Technology
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

  • Hyeonsu Lee

    (Korea Advanced Institute of Science and Technology)

  • Se-Bum Paik

    (Korea Advanced Institute of Science and Technology
    Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology)

  • Min Whan Jung

    (Korea Advanced Institute of Science and Technology
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

Abstract

It is unclear how different types of cortical projection neurons work together to support diverse cortical functions. We examined the discharge characteristics and inactivation effects of intratelencephalic (IT) and pyramidal tract (PT) neurons—two major types of cortical excitatory neurons that project to cortical and subcortical structures, respectively—in the deep layer of the medial prefrontal cortex in mice performing a delayed response task. We found stronger target-dependent firing of IT than PT neurons during the delay period. We also found the inactivation of IT neurons, but not PT neurons, impairs behavioral performance. In contrast, PT neurons carry more temporal information than IT neurons during the delay period. Our results indicate a division of labor between IT and PT projection neurons in the prefrontal cortex for the maintenance of working memory and for tracking the passage of time, respectively.

Suggested Citation

  • Jung Won Bae & Huijeong Jeong & Young Ju Yoon & Chan Mee Bae & Hyeonsu Lee & Se-Bum Paik & Min Whan Jung, 2021. "Parallel processing of working memory and temporal information by distinct types of cortical projection neurons," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24565-z
    DOI: 10.1038/s41467-021-24565-z
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    Cited by:

    1. Hannah Muysers & Hung-Ling Chen & Johannes Hahn & Shani Folschweiller & Torfi Sigurdsson & Jonas-Frederic Sauer & Marlene Bartos, 2024. "A persistent prefrontal reference frame across time and task rules," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Huee Ru Chong & Yadollah Ranjbar-Slamloo & Malcolm Zheng Hao Ho & Xuan Ouyang & Tsukasa Kamigaki, 2023. "Functional alterations of the prefrontal circuit underlying cognitive aging in mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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