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Osteocyte mitochondria regulate angiogenesis of transcortical vessels

Author

Listed:
  • Peng Liao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Long Chen

    (Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences)

  • Hao Zhou

    (The Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Jiong Mei

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Ziming Chen

    (Medical School, The University of Western Australia
    Perron Institute for Neurological and Translational Science)

  • Bingqi Wang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jerry Q. Feng

    (Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials)

  • Guangyi Li

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Sihan Tong

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jian Zhou

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Siyuan Zhu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yu Qian

    (The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine))

  • Yao Zong

    (Medical School, The University of Western Australia
    Perron Institute for Neurological and Translational Science)

  • Weiguo Zou

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences)

  • Hao Li

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Wenkan Zhang

    (The Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Meng Yao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yiyang Ma

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Peng Ding

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yidan Pang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Chuan Gao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jialun Mei

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Senyao Zhang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Changqing Zhang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Delin Liu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Minghao Zheng

    (Medical School, The University of Western Australia
    Perron Institute for Neurological and Translational Science)

  • Junjie Gao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

Abstract

Transcortical vessels (TCVs) provide effective communication between bone marrow vascular system and external circulation. Although osteocytes are in close contact with them, it is not clear whether osteocytes regulate the homeostasis of TCVs. Here, we show that osteocytes maintain the normal network of TCVs by transferring mitochondria to the endothelial cells of TCV. Partial ablation of osteocytes causes TCV regression. Inhibition of mitochondrial transfer by conditional knockout of Rhot1 in osteocytes also leads to regression of the TCV network. By contrast, acquisition of osteocyte mitochondria by endothelial cells efficiently restores endothelial dysfunction. Administration of osteocyte mitochondria resultes in acceleration of the angiogenesis and healing of the cortical bone defect. Our results provide new insights into osteocyte-TCV interactions and inspire the potential application of mitochondrial therapy for bone-related diseases.

Suggested Citation

  • Peng Liao & Long Chen & Hao Zhou & Jiong Mei & Ziming Chen & Bingqi Wang & Jerry Q. Feng & Guangyi Li & Sihan Tong & Jian Zhou & Siyuan Zhu & Yu Qian & Yao Zong & Weiguo Zou & Hao Li & Wenkan Zhang & , 2024. "Osteocyte mitochondria regulate angiogenesis of transcortical vessels," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46095-0
    DOI: 10.1038/s41467-024-46095-0
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