IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v498y2013i7452d10.1038_nature12154.html
   My bibliography  Save this article

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Author

Listed:
  • Joanna Kaplon

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Liang Zheng

    (Cancer Research UK, Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Katrin Meissl

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Barbara Chaneton

    (Cancer Research UK, Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Vitaly A. Selivanov

    (Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028 Barcelona, Spain
    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-153, 08036 Barcelona, Spain)

  • Gillian Mackay

    (Cancer Research UK, Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Sjoerd H. van der Burg

    (Experimental Cancer Immunology and Therapy, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands)

  • Elizabeth M. E. Verdegaal

    (Experimental Cancer Immunology and Therapy, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands)

  • Marta Cascante

    (Faculty of Biology, Universitat de Barcelona, Av Diagonal 643, 08028 Barcelona, Spain
    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-153, 08036 Barcelona, Spain)

  • Tomer Shlomi

    (Technion, Israel Institute of Technology, Haifa 32000, Israel
    Lewis-Sigler Institute for Integrative Genomics, Princeton University)

  • Eyal Gottlieb

    (Cancer Research UK, Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Daniel S. Peeper

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

Abstract

Pyruvate dehydrogenase (PDH) is identified as a crucial mediator of BRAFV600E-induced cellular senescence: PDH is activated by BRAF-mediated suppression of PDK1, enhancing oxidative glucose metabolism, and PDK1 depletion eradicates mutant BRAF melanomas, indicating that this relationship between cell senescence and metabolism might be exploited therapeutically.

Suggested Citation

  • Joanna Kaplon & Liang Zheng & Katrin Meissl & Barbara Chaneton & Vitaly A. Selivanov & Gillian Mackay & Sjoerd H. van der Burg & Elizabeth M. E. Verdegaal & Marta Cascante & Tomer Shlomi & Eyal Gottli, 2013. "A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence," Nature, Nature, vol. 498(7452), pages 109-112, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12154
    DOI: 10.1038/nature12154
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12154
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12154?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Martina Troiani & Manuel Colucci & Mariantonietta D’Ambrosio & Ilaria Guccini & Emiliano Pasquini & Angelica Varesi & Aurora Valdata & Simone Mosole & Ajinkya Revandkar & Giuseppe Attanasio & Andrea R, 2022. "Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Peng Liao & Long Chen & Hao Zhou & Jiong Mei & Ziming Chen & Bingqi Wang & Jerry Q. Feng & Guangyi Li & Sihan Tong & Jian Zhou & Siyuan Zhu & Yu Qian & Yao Zong & Weiguo Zou & Hao Li & Wenkan Zhang & , 2024. "Osteocyte mitochondria regulate angiogenesis of transcortical vessels," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Yinsheng Wu & Lixu Tang & Han Huang & Qi Yu & Bicheng Hu & Gang Wang & Feng Ge & Tailang Yin & Shanshan Li & Xilan Yu, 2023. "Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Chen Wang & Hideki Tanizawa & Connor Hill & Aaron Havas & Qiang Zhang & Liping Liao & Xue Hao & Xue Lei & Lu Wang & Hao Nie & Yuan Qi & Bin Tian & Alessandro Gardini & Andrew V. Kossenkov & Aaron Gold, 2024. "METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12154. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.