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Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Author

Listed:
  • Saravana K. Ramasamy

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany)

  • Anjali P. Kusumbe

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany)

  • Lin Wang

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany)

  • Ralf H. Adams

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

Abstract

Blood vessel growth in bone is revealed to require Notch signalling and involve a specialized form of angiogenesis that does not involve endothelial sprouts.

Suggested Citation

  • Saravana K. Ramasamy & Anjali P. Kusumbe & Lin Wang & Ralf H. Adams, 2014. "Endothelial Notch activity promotes angiogenesis and osteogenesis in bone," Nature, Nature, vol. 507(7492), pages 376-380, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature13146
    DOI: 10.1038/nature13146
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    1. Joschka Heil & Victor Olsavszky & Katrin Busch & Kay Klapproth & Carolina Torre & Carsten Sticht & Kajetan Sandorski & Johannes Hoffmann & Hiltrud Schönhaber & Johanna Zierow & Manuel Winkler & Christ, 2021. "Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Nicolas Verheyen & Astrid Fahrleitner-Pammer & Evgeny Belyavskiy & Martin R Gruebler & Hans Peter Dimai & Karin Amrein & Klemens Ablasser & Johann Martensen & Cristiana Catena & Elisabeth Pieske-Kraig, 2017. "Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-10, April.
    3. Alexandra N. Rindone & Xiaonan Liu & Stephanie Farhat & Alexander Perdomo-Pantoja & Timothy F. Witham & Daniel L. Coutu & Mei Wan & Warren L. Grayson, 2021. "Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    4. Peng Liao & Long Chen & Hao Zhou & Jiong Mei & Ziming Chen & Bingqi Wang & Jerry Q. Feng & Guangyi Li & Sihan Tong & Jian Zhou & Siyuan Zhu & Yu Qian & Yao Zong & Weiguo Zou & Hao Li & Wenkan Zhang & , 2024. "Osteocyte mitochondria regulate angiogenesis of transcortical vessels," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. M. Gabriele Bixel & Kishor K. Sivaraj & Melanie Timmen & Vishal Mohanakrishnan & Anusha Aravamudhan & Susanne Adams & Bong-Ihn Koh & Hyun-Woo Jeong & Kai Kruse & Richard Stange & Ralf H. Adams, 2024. "Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    6. Maria Dzamukova & Tobias M. Brunner & Jadwiga Miotla-Zarebska & Frederik Heinrich & Laura Brylka & Mir-Farzin Mashreghi & Anjali Kusumbe & Ralf Kühn & Thorsten Schinke & Tonia L. Vincent & Max Löhning, 2022. "Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    7. Till Fabian Mertens & Alina Tabea Liebheit & Johanna Ehl & Ralf Köhler & Asylkhan Rakhymzhan & Andrew Woehler & Lukas Katthän & Gernot Ebel & Wjatscheslaw Liublin & Ana Kasapi & Antigoni Triantafyllop, 2024. "MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    9. Laetitia Préau & Anna Lischke & Melanie Merkel & Neslihan Oegel & Maria Weissenbruch & Andria Michael & Hongryeol Park & Dietmar Gradl & Christian Kupatt & Ferdinand Noble, 2024. "Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    10. Haruko Watanabe-Takano & Katsuhiro Kato & Eri Oguri-Nakamura & Tomohiro Ishii & Koji Kobayashi & Takahisa Murata & Koichiro Tsujikawa & Takaki Miyata & Yoshiaki Kubota & Yasuyuki Hanada & Koichi Nishi, 2024. "Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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