IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v507y2014i7492d10.1038_nature13146.html
   My bibliography  Save this article

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Author

Listed:
  • Saravana K. Ramasamy

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany)

  • Anjali P. Kusumbe

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany)

  • Lin Wang

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany)

  • Ralf H. Adams

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

Abstract

Blood vessel growth in bone is revealed to require Notch signalling and involve a specialized form of angiogenesis that does not involve endothelial sprouts.

Suggested Citation

  • Saravana K. Ramasamy & Anjali P. Kusumbe & Lin Wang & Ralf H. Adams, 2014. "Endothelial Notch activity promotes angiogenesis and osteogenesis in bone," Nature, Nature, vol. 507(7492), pages 376-380, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature13146
    DOI: 10.1038/nature13146
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13146
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13146?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nicolas Verheyen & Astrid Fahrleitner-Pammer & Evgeny Belyavskiy & Martin R Gruebler & Hans Peter Dimai & Karin Amrein & Klemens Ablasser & Johann Martensen & Cristiana Catena & Elisabeth Pieske-Kraig, 2017. "Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-10, April.
    2. Alexandra N. Rindone & Xiaonan Liu & Stephanie Farhat & Alexander Perdomo-Pantoja & Timothy F. Witham & Daniel L. Coutu & Mei Wan & Warren L. Grayson, 2021. "Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Peng Liao & Long Chen & Hao Zhou & Jiong Mei & Ziming Chen & Bingqi Wang & Jerry Q. Feng & Guangyi Li & Sihan Tong & Jian Zhou & Siyuan Zhu & Yu Qian & Yao Zong & Weiguo Zou & Hao Li & Wenkan Zhang & , 2024. "Osteocyte mitochondria regulate angiogenesis of transcortical vessels," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. M. Gabriele Bixel & Kishor K. Sivaraj & Melanie Timmen & Vishal Mohanakrishnan & Anusha Aravamudhan & Susanne Adams & Bong-Ihn Koh & Hyun-Woo Jeong & Kai Kruse & Richard Stange & Ralf H. Adams, 2024. "Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    5. Maria Dzamukova & Tobias M. Brunner & Jadwiga Miotla-Zarebska & Frederik Heinrich & Laura Brylka & Mir-Farzin Mashreghi & Anjali Kusumbe & Ralf Kühn & Thorsten Schinke & Tonia L. Vincent & Max Löhning, 2022. "Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Till Fabian Mertens & Alina Tabea Liebheit & Johanna Ehl & Ralf Köhler & Asylkhan Rakhymzhan & Andrew Woehler & Lukas Katthän & Gernot Ebel & Wjatscheslaw Liublin & Ana Kasapi & Antigoni Triantafyllop, 2024. "MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    7. Haruko Watanabe-Takano & Katsuhiro Kato & Eri Oguri-Nakamura & Tomohiro Ishii & Koji Kobayashi & Takahisa Murata & Koichiro Tsujikawa & Takaki Miyata & Yoshiaki Kubota & Yasuyuki Hanada & Koichi Nishi, 2024. "Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Joschka Heil & Victor Olsavszky & Katrin Busch & Kay Klapproth & Carolina Torre & Carsten Sticht & Kajetan Sandorski & Johannes Hoffmann & Hiltrud Schönhaber & Johanna Zierow & Manuel Winkler & Christ, 2021. "Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    9. Raymond K. H. Yip & Joel S. Rimes & Bianca D. Capaldo & François Vaillant & Kellie A. Mouchemore & Bhupinder Pal & Yunshun Chen & Elliot Surgenor & Andrew J. Murphy & Robin L. Anderson & Gordon K. Smy, 2021. "Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    10. Laetitia Préau & Anna Lischke & Melanie Merkel & Neslihan Oegel & Maria Weissenbruch & Andria Michael & Hongryeol Park & Dietmar Gradl & Christian Kupatt & Ferdinand Noble, 2024. "Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature13146. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.