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Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

Author

Listed:
  • Ting Huang

    (Zhejiang University)

  • Ruyi Lin

    (Zhejiang University)

  • Yuanqin Su

    (Zhejiang University
    Zhejiang University)

  • Hao Sun

    (Zhejiang University)

  • Xixi Zheng

    (Zhejiang University
    Zhejiang University)

  • Jinsong Zhang

    (Zhejiang University)

  • Xiaoyan Lu

    (Zhejiang University)

  • Baiqin Zhao

    (Zhejiang University School of Medicine)

  • Xinchi Jiang

    (Zhejiang University)

  • Lingling Huang

    (Zhejiang University School of Medicine)

  • Ni Li

    (Ningbo University)

  • Jing Shi

    (Hangzhou Medical College)

  • Xiaohui Fan

    (Zhejiang University
    Zhejiang University)

  • Donghang Xu

    (Zhejiang University School of Medicine)

  • Tianyuan Zhang

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Jianqing Gao

    (Zhejiang University
    Zhejiang University
    Zhejiang University School of Medicine
    Zhejiang University)

Abstract

The use of exogenous mitochondria to replenish damaged mitochondria has been proposed as a strategy for the treatment of pulmonary fibrosis. However, the success of this strategy is partially restricted by the difficulty of supplying sufficient mitochondria to diseased cells. Herein, we report the generation of high-powered mesenchymal stem cells with promoted mitochondrial biogenesis and facilitated mitochondrial transfer to injured lung cells by the sequential treatment of pioglitazone and iron oxide nanoparticles. This highly efficient mitochondrial transfer is shown to not only restore mitochondrial homeostasis but also reactivate inhibited mitophagy, consequently recovering impaired cellular functions. We perform studies in mouse to show that these high-powered mesenchymal stem cells successfully mitigate fibrotic progression in a progressive fibrosis model, which was further verified in a humanized multicellular lung spheroid model. The present findings provide a potential strategy to overcome the current limitations in mitochondrial replenishment therapy, thereby promoting therapeutic applications for fibrotic intervention.

Suggested Citation

  • Ting Huang & Ruyi Lin & Yuanqin Su & Hao Sun & Xixi Zheng & Jinsong Zhang & Xiaoyan Lu & Baiqin Zhao & Xinchi Jiang & Lingling Huang & Ni Li & Jing Shi & Xiaohui Fan & Donghang Xu & Tianyuan Zhang & J, 2023. "Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41529-7
    DOI: 10.1038/s41467-023-41529-7
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    References listed on IDEAS

    as
    1. Kazuhide Hayakawa & Elga Esposito & Xiaohua Wang & Yasukazu Terasaki & Yi Liu & Changhong Xing & Xunming Ji & Eng H. Lo, 2016. "Transfer of mitochondria from astrocytes to neurons after stroke," Nature, Nature, vol. 535(7613), pages 551-555, July.
    2. Kazuhide Hayakawa & Elga Esposito & Xiaohua Wang & Yasukazu Terasaki & Yi Liu & Changhong Xing & Xunming Ji & Eng H. Lo, 2016. "Correction: Corrigendum: Transfer of mitochondria from astrocytes to neurons after stroke," Nature, Nature, vol. 539(7627), pages 123-123, November.
    3. Karolina Piekarska & Zuzanna Urban-Wójciuk & Małgorzta Kurkowiak & Iwona Pelikant-Małecka & Adriana Schumacher & Justyna Sakowska & Jan Henryk Spodnik & Łukasz Arcimowicz & Hanna Zielińska & Bogusław , 2022. "Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Michael T. Lin & M. Flint Beal, 2006. "Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases," Nature, Nature, vol. 443(7113), pages 787-795, October.
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    Cited by:

    1. Peng Liao & Long Chen & Hao Zhou & Jiong Mei & Ziming Chen & Bingqi Wang & Jerry Q. Feng & Guangyi Li & Sihan Tong & Jian Zhou & Siyuan Zhu & Yu Qian & Yao Zong & Weiguo Zou & Hao Li & Wenkan Zhang & , 2024. "Osteocyte mitochondria regulate angiogenesis of transcortical vessels," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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