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Transfer of mitochondria from astrocytes to neurons after stroke

Author

Listed:
  • Kazuhide Hayakawa

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Elga Esposito

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Xiaohua Wang

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
    Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University)

  • Yasukazu Terasaki

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Yi Liu

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School
    Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University)

  • Changhong Xing

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Xunming Ji

    (Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University)

  • Eng H. Lo

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

Abstract

In a mouse model of ischaemia, mitochondrial particles released from astroctyes are taken up by adjacent neurons, leading to enhanced cell survival signalling; disruption of this release mechanism resulted in worsened neurological outcomes.

Suggested Citation

  • Kazuhide Hayakawa & Elga Esposito & Xiaohua Wang & Yasukazu Terasaki & Yi Liu & Changhong Xing & Xunming Ji & Eng H. Lo, 2016. "Transfer of mitochondria from astrocytes to neurons after stroke," Nature, Nature, vol. 535(7613), pages 551-555, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18928
    DOI: 10.1038/nature18928
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    Cited by:

    1. Peng Liao & Long Chen & Hao Zhou & Jiong Mei & Ziming Chen & Bingqi Wang & Jerry Q. Feng & Guangyi Li & Sihan Tong & Jian Zhou & Siyuan Zhu & Yu Qian & Yao Zong & Weiguo Zou & Hao Li & Wenkan Zhang & , 2024. "Osteocyte mitochondria regulate angiogenesis of transcortical vessels," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Ting Huang & Ruyi Lin & Yuanqin Su & Hao Sun & Xixi Zheng & Jinsong Zhang & Xiaoyan Lu & Baiqin Zhao & Xinchi Jiang & Lingling Huang & Ni Li & Jing Shi & Xiaohui Fan & Donghang Xu & Tianyuan Zhang & J, 2023. "Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Jiayi Wang & Mengke Zhao & Meina Wang & Dong Fu & Lin Kang & Yu Xu & Liming Shen & Shilin Jin & Liang Wang & Jing Liu, 2024. "Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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