A release of local subunit conformational heterogeneity underlies gating in a muscle nicotinic acetylcholine receptor
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DOI: 10.1038/s41467-024-46028-x
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- Nicolas Bocquet & Hugues Nury & Marc Baaden & Chantal Le Poupon & Jean-Pierre Changeux & Marc Delarue & Pierre-Jean Corringer, 2009. "X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation," Nature, Nature, vol. 457(7225), pages 111-114, January.
- Jeong Joo Kim & Anant Gharpure & Jinfeng Teng & Yuxuan Zhuang & Rebecca J. Howard & Shaotong Zhu & Colleen M. Noviello & Richard M. Walsh & Erik Lindahl & Ryan E. Hibbs, 2020. "Shared structural mechanisms of general anaesthetics and benzodiazepines," Nature, Nature, vol. 585(7824), pages 303-308, September.
- Won Yong Lee & Steven M. Sine, 2005. "Principal pathway coupling agonist binding to channel gating in nicotinic receptors," Nature, Nature, vol. 438(7065), pages 243-247, November.
- Lucie Polovinkin & Ghérici Hassaine & Jonathan Perot & Emmanuelle Neumann & Anders A. Jensen & Solène N. Lefebvre & Pierre-Jean Corringer & Jacques Neyton & Christophe Chipot & Francois Dehez & Guy S, 2018. "Conformational transitions of the serotonin 5-HT3 receptor," Nature, Nature, vol. 563(7730), pages 275-279, November.
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