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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Author

Listed:
  • Nicolas Bocquet

    (Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182)

  • Hugues Nury

    (Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182
    Pasteur Institute, Unit of Structural Dynamics of Macromolecules, CNRS URA 2185)

  • Marc Baaden

    (Institut de Biologie Physico-Chimique, CNRS UPR 9080, 75005 Paris, France)

  • Chantal Le Poupon

    (Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182)

  • Jean-Pierre Changeux

    (Pasteur Institute, CNRS URA 2182, F75015, Paris, France)

  • Marc Delarue

    (Pasteur Institute, Unit of Structural Dynamics of Macromolecules, CNRS URA 2185)

  • Pierre-Jean Corringer

    (Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182)

Abstract

ELIC channel structure Recently, the first crystal structure of a pentameric ligand-gated ion channel known as GLIC was published, which represented a closed state of the channel. Two papers in this issue report the crystal structures of the presumptive open states of a related channel — ELIC —and show significant tilting of the M2 and M3 α-helices from the closed state.

Suggested Citation

  • Nicolas Bocquet & Hugues Nury & Marc Baaden & Chantal Le Poupon & Jean-Pierre Changeux & Marc Delarue & Pierre-Jean Corringer, 2009. "X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation," Nature, Nature, vol. 457(7225), pages 111-114, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7225:d:10.1038_nature07462
    DOI: 10.1038/nature07462
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    Citations

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    Cited by:

    1. David Mowrey & Qiang Chen & Yuhe Liang & Jie Liang & Yan Xu & Pei Tang, 2013. "Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.
    2. Nikhil Bharambe & Zhuowen Li & David Seiferth & Asha Manikkoth Balakrishna & Philip C. Biggin & Sandip Basak, 2024. "Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Mackenzie J. Thompson & Farid Mansoub Bekarkhanechi & Anna Ananchenko & Hugues Nury & John E. Baenziger, 2024. "A release of local subunit conformational heterogeneity underlies gating in a muscle nicotinic acetylcholine receptor," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. John T. Petroff & Noah M. Dietzen & Ezry Santiago-McRae & Brett Deng & Maya S. Washington & Lawrence J. Chen & K. Trent Moreland & Zengqin Deng & Michael Rau & James A. J. Fitzpatrick & Peng Yuan & Th, 2022. "Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Kurt T Laha & Borna Ghosh & Cynthia Czajkowski, 2013. "Macroscopic Kinetics of Pentameric Ligand Gated Ion Channels: Comparisons between Two Prokaryotic Channels and One Eukaryotic Channel," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-9, November.

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