IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45434-5.html
   My bibliography  Save this article

Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses

Author

Listed:
  • Yuting Li

    (Purdue University
    Purdue University)

  • Zongyue Cheng

    (Purdue University
    Purdue University)

  • Chenmao Wang

    (Purdue University
    Purdue University)

  • Jianian Lin

    (Purdue University
    Purdue University)

  • Hehai Jiang

    (Purdue University
    Purdue University)

  • Meng Cui

    (Purdue University
    Purdue University
    Purdue University)

Abstract

The advance of genetic function indicators has enabled the observation of neuronal activities at single-cell resolutions. A major challenge for the applications on mammalian brains is the limited optical access depth. Currently, the method of choice to access deep brain structures is to insert miniature optical components. Among these validated miniature optics, the gradient-index (GRIN) lens has been widely employed for its compactness and simplicity. However, due to strong fourth-order astigmatism, GRIN lenses suffer from a small imaging field of view, which severely limits the measurement throughput and success rate. To overcome these challenges, we developed geometric transformation adaptive optics (GTAO), which enables adaptable achromatic large-volume correction through GRIN lenses. We demonstrate its major advances through in vivo structural and functional imaging of mouse brains. The results suggest that GTAO can serve as a versatile solution to enable large-volume recording of deep brain structures and activities through GRIN lenses.

Suggested Citation

  • Yuting Li & Zongyue Cheng & Chenmao Wang & Jianian Lin & Hehai Jiang & Meng Cui, 2024. "Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45434-5
    DOI: 10.1038/s41467-024-45434-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45434-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45434-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jianian Lin & Zongyue Cheng & Guang Yang & Meng Cui, 2022. "Optical gearbox enabled versatile multiscale high-throughput multiphoton functional imaging," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Karel Svoboda & Winfried Denk & David Kleinfeld & David W. Tank, 1997. "In vivo dendritic calcium dynamics in neocortical pyramidal neurons," Nature, Nature, vol. 385(6612), pages 161-165, January.
    3. Joshua T. Trachtenberg & Brian E. Chen & Graham W. Knott & Guoping Feng & Joshua R. Sanes & Egbert Welker & Karel Svoboda, 2002. "Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex," Nature, Nature, vol. 420(6917), pages 788-794, December.
    4. Yan Zhang & Márton Rózsa & Yajie Liang & Daniel Bushey & Ziqiang Wei & Jihong Zheng & Daniel Reep & Gerard Joey Broussard & Arthur Tsang & Getahun Tsegaye & Sujatha Narayan & Christopher J. Obara & Ji, 2023. "Fast and sensitive GCaMP calcium indicators for imaging neural populations," Nature, Nature, vol. 615(7954), pages 884-891, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marie A. Labouesse & Arturo Torres-Herraez & Muhammad O. Chohan & Joseph M. Villarin & Julia Greenwald & Xiaoxiao Sun & Mysarah Zahran & Alice Tang & Sherry Lam & Jeremy Veenstra-VanderWeele & Clay O., 2023. "A non-canonical striatopallidal Go pathway that supports motor control," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Shahram Bahrami & Kaja Nordengen & Jaroslav Rokicki & Alexey A. Shadrin & Zillur Rahman & Olav B. Smeland & Piotr P. Jaholkowski & Nadine Parker & Pravesh Parekh & Kevin S. O’Connell & Torbjørn Elvsås, 2024. "The genetic landscape of basal ganglia and implications for common brain disorders," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Aniruddha Das & Sarah Holden & Julie Borovicka & Jacob Icardi & Abigail O’Niel & Ariel Chaklai & Davina Patel & Rushik Patel & Stefanie Kaech Petrie & Jacob Raber & Hod Dana, 2023. "Large-scale recording of neuronal activity in freely-moving mice at cellular resolution," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Quanyu Zhou & Chaim Glück & Lin Tang & Lukas Glandorf & Jeanne Droux & Mohamad El Amki & Susanne Wegener & Bruno Weber & Daniel Razansky & Zhenyue Chen, 2024. "Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Thanh-an Pham & Aleix Boquet-Pujadas & Sandip Mondal & Michael Unser & George Barbastathis, 2024. "Deep-prior ODEs augment fluorescence imaging with chemical sensors," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Hiromu Takizawa & Noriko Hiroi & Akira Funahashi, 2012. "Mathematical Modeling of Sustainable Synaptogenesis by Repetitive Stimuli Suggests Signaling Mechanisms In Vivo," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-22, December.
    7. Laura Hermans & Murat Kaynak & Jonas Braun & Victor Lobato Ríos & Chin-Lin Chen & Adam Friedberg & Semih Günel & Florian Aymanns & Mahmut Selman Sakar & Pavan Ramdya, 2022. "Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    8. P. Dylan Rich & Stephan Yves Thiberge & Benjamin B. Scott & Caiying Guo & D. Gowanlock R. Tervo & Carlos D. Brody & Alla Y. Karpova & Nathaniel D. Daw & David W. Tank, 2024. "Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    9. Yichen Zhang & Gan He & Lei Ma & Xiaofei Liu & J. J. Johannes Hjorth & Alexander Kozlov & Yutao He & Shenjian Zhang & Jeanette Hellgren Kotaleski & Yonghong Tian & Sten Grillner & Kai Du & Tiejun Huan, 2023. "A GPU-based computational framework that bridges neuron simulation and artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    10. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    11. Caio Vaz Rimoli & Claudio Moretti & Fernando Soldevila & Enora Brémont & Cathie Ventalon & Sylvain Gigan, 2024. "Demixing fluorescence time traces transmitted by multimode fibers," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    12. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    13. Yusuke Nasu & Abhi Aggarwal & Giang N. T. Le & Camilla Trang Vo & Yuki Kambe & Xinxing Wang & Felix R. M. Beinlich & Ashley Bomin Lee & Tina R. Ram & Fangying Wang & Kelsea A. Gorzo & Yuki Kamijo & Ma, 2023. "Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    14. Natalia V. Barykina & Erin M. Carey & Olena S. Oliinyk & Axel Nimmerjahn & Vladislav V. Verkhusha, 2024. "Destabilized near-infrared fluorescent nanobodies enable background-free targeting of GFP-based biosensors for imaging and manipulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    15. Eiji Shigetomi & Hideaki Suzuki & Yukiho J. Hirayama & Fumikazu Sano & Yuki Nagai & Kohei Yoshihara & Keisuke Koga & Toru Tateoka & Hideyuki Yoshioka & Youichi Shinozaki & Hiroyuki Kinouchi & Kenji F., 2024. "Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    16. Romain Daniel Cazé & Mark Humphries & Boris Gutkin, 2013. "Passive Dendrites Enable Single Neurons to Compute Linearly Non-separable Functions," PLOS Computational Biology, Public Library of Science, vol. 9(2), pages 1-15, February.
    17. Maximilian Hoffmann & Jörg Henninger & Johannes Veith & Lars Richter & Benjamin Judkewitz, 2023. "Blazed oblique plane microscopy reveals scale-invariant inference of brain-wide population activity," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    18. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-22, December.
    19. Camille Mazo & Margarida Baeta & Leopoldo Petreanu, 2024. "Auditory cortex conveys non-topographic sound localization signals to visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    20. Wei Chen & Ryan G. Natan & Yuhan Yang & Shih-Wei Chou & Qinrong Zhang & Ehud Y. Isacoff & Na Ji, 2021. "In vivo volumetric imaging of calcium and glutamate activity at synapses with high spatiotemporal resolution," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45434-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.