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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

Author

Listed:
  • Joshua T. Trachtenberg

    (Howard Hughes Medical Institute, Cold Spring Harbor Laboratory)

  • Brian E. Chen

    (Howard Hughes Medical Institute, Cold Spring Harbor Laboratory)

  • Graham W. Knott

    (Université de Lausanne)

  • Guoping Feng

    (Washington University School of Medicine)

  • Joshua R. Sanes

    (Washington University School of Medicine)

  • Egbert Welker

    (Université de Lausanne)

  • Karel Svoboda

    (Howard Hughes Medical Institute, Cold Spring Harbor Laboratory)

Abstract

Do new synapses form in the adult cortex to support experience-dependent plasticity? To address this question, we repeatedly imaged individual pyramidal neurons in the mouse barrel cortex over periods of weeks. We found that, although dendritic structure is stable, some spines appear and disappear. Spine lifetimes vary greatly: stable spines, about 50% of the population, persist for at least a month, whereas the remainder are present for a few days or less. Serial-section electron microscopy of imaged dendritic segments revealed retrospectively that spine sprouting and retraction are associated with synapse formation and elimination. Experience-dependent plasticity of cortical receptive fields was accompanied by increased synapse turnover. Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.

Suggested Citation

  • Joshua T. Trachtenberg & Brian E. Chen & Graham W. Knott & Guoping Feng & Joshua R. Sanes & Egbert Welker & Karel Svoboda, 2002. "Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex," Nature, Nature, vol. 420(6917), pages 788-794, December.
    • Handle: RePEc:nat:nature:v:420:y:2002:i:6917:d:10.1038_nature01273
    DOI: 10.1038/nature01273
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    Cited by:

    1. Yichen Zhang & Gan He & Lei Ma & Xiaofei Liu & J. J. Johannes Hjorth & Alexander Kozlov & Yutao He & Shenjian Zhang & Jeanette Hellgren Kotaleski & Yonghong Tian & Sten Grillner & Kai Du & Tiejun Huan, 2023. "A GPU-based computational framework that bridges neuron simulation and artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    3. Yuting Li & Zongyue Cheng & Chenmao Wang & Jianian Lin & Hehai Jiang & Meng Cui, 2024. "Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Hiromu Takizawa & Noriko Hiroi & Akira Funahashi, 2012. "Mathematical Modeling of Sustainable Synaptogenesis by Repetitive Stimuli Suggests Signaling Mechanisms In Vivo," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-22, December.
    5. Laura Hermans & Murat Kaynak & Jonas Braun & Victor Lobato Ríos & Chin-Lin Chen & Adam Friedberg & Semih Günel & Florian Aymanns & Mahmut Selman Sakar & Pavan Ramdya, 2022. "Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-22, December.
    7. P. Dylan Rich & Stephan Yves Thiberge & Benjamin B. Scott & Caiying Guo & D. Gowanlock R. Tervo & Carlos D. Brody & Alla Y. Karpova & Nathaniel D. Daw & David W. Tank, 2024. "Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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