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The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids

Author

Listed:
  • Gabriel Lachance

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval
    Centre de recherche de l’IUCPQ)

  • Karine Robitaille

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • Jalal Laaraj

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • Nikunj Gevariya

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • Thibault V. Varin

    (Centre de recherche de l’IUCPQ)

  • Andrei Feldiorean

    (Research Institute of the McGill University Health Centre
    McGill University)

  • Fanny Gaignier

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • Isabelle Bourdeau Julien

    (health and society of Université Laval)

  • Hui Wen Xu

    (Université Laval)

  • Tarek Hallal

    (Research Institute of the McGill University Health Centre
    McGill University)

  • Jean-François Pelletier

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • Sidki Bouslama

    (Université Laval)

  • Nadia Boufaied

    (Research Institute of the McGill University Health Centre)

  • Nicolas Derome

    (Université Laval
    Université Laval)

  • Alain Bergeron

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • Leigh Ellis

    (Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Ciriaco A. Piccirillo

    (Research Institute of the McGill University Health Centre
    McGill University)

  • Frédéric Raymond

    (health and society of Université Laval)

  • Yves Fradet

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval)

  • David P. Labbé

    (Research Institute of the McGill University Health Centre
    McGill University
    McGill University)

  • André Marette

    (Centre de recherche de l’IUCPQ)

  • Vincent Fradet

    (Oncology Axis, Centre de recherche du CHU de Québec-Université Laval
    Centre de recherche sur le Cancer de l’Université Laval
    health and society of Université Laval)

Abstract

The gut microbiota modulates response to hormonal treatments in prostate cancer (PCa) patients, but whether it influences PCa progression remains unknown. Here, we show a reduction in fecal microbiota alpha-diversity correlating with increase tumour burden in two distinct groups of hormonotherapy naïve PCa patients and three murine PCa models. Fecal microbiota transplantation (FMT) from patients with high PCa volume is sufficient to stimulate the growth of mouse PCa revealing the existence of a gut microbiome-cancer crosstalk. Analysis of gut microbial-related pathways in mice with aggressive PCa identifies three enzymes responsible for the metabolism of long-chain fatty acids (LCFA). Supplementation with LCFA omega-3 MAG-EPA is sufficient to reduce PCa growth in mice and cancer up-grading in pre-prostatectomy PCa patients correlating with a reduction of gut Ruminococcaceae in both and fecal butyrate levels in PCa patients. This suggests that the beneficial effect of omega-3 rich diet is mediated in part by modulating the crosstalk between gut microbes and their metabolites in men with PCa.

Suggested Citation

  • Gabriel Lachance & Karine Robitaille & Jalal Laaraj & Nikunj Gevariya & Thibault V. Varin & Andrei Feldiorean & Fanny Gaignier & Isabelle Bourdeau Julien & Hui Wen Xu & Tarek Hallal & Jean-François Pe, 2024. "The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45332-w
    DOI: 10.1038/s41467-024-45332-w
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    References listed on IDEAS

    as
    1. Aaron C Ericsson & J Wade Davis & William Spollen & Nathan Bivens & Scott Givan & Catherine E Hagan & Mark McIntosh & Craig L Franklin, 2015. "Effects of Vendor and Genetic Background on the Composition of the Fecal Microbiota of Inbred Mice," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-19, February.
    2. Clélia Coutzac & Jean-Mehdi Jouniaux & Angelo Paci & Julien Schmidt & Domenico Mallardo & Atmane Seck & Vahe Asvatourian & Lydie Cassard & Patrick Saulnier & Ludovic Lacroix & Paul-Louis Woerther & Au, 2020. "Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    3. Brendan A. Daisley & Ryan M. Chanyi & Kamilah Abdur-Rashid & Kait F. Al & Shaeley Gibbons & John A. Chmiel & Hannah Wilcox & Gregor Reid & Amanda Anderson & Malcolm Dewar & Shiva M. Nair & Joseph Chin, 2020. "Author Correction: Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients," Nature Communications, Nature, vol. 11(1), pages 1-1, December.
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