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Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

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  • Junki Miyamoto

    (Tokyo University of Agriculture and Technology
    AMED-CREST, Japan Agency for Medical Research and Development)

  • Miki Igarashi

    (Tokyo University of Agriculture and Technology)

  • Keita Watanabe

    (Tokyo University of Agriculture and Technology)

  • Shin-ichiro Karaki

    (University of Shizuoka)

  • Hiromi Mukouyama

    (Tokyo University of Agriculture and Technology)

  • Shigenobu Kishino

    (Kyoto University, Kitashirakawa Oiwake-cho)

  • Xuan Li

    (Tokyo University of Agriculture and Technology)

  • Atsuhiko Ichimura

    (Kyoto University
    K-CONNEX, Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research)

  • Junichiro Irie

    (AMED-CREST, Japan Agency for Medical Research and Development
    Keio University, Shinjuku-ku)

  • Yukihiko Sugimoto

    (AMED-CREST, Japan Agency for Medical Research and Development
    Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University)

  • Tetsuya Mizutani

    (Tokyo University of Agriculture and Technology)

  • Tatsuya Sugawara

    (Kyoto University)

  • Takashi Miki

    (Chiba University)

  • Jun Ogawa

    (Kyoto University, Kitashirakawa Oiwake-cho)

  • Daniel J. Drucker

    (University of Toronto)

  • Makoto Arita

    (Keio University
    Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences)

  • Hiroshi Itoh

    (AMED-CREST, Japan Agency for Medical Research and Development
    Keio University, Shinjuku-ku)

  • Ikuo Kimura

    (Tokyo University of Agriculture and Technology
    AMED-CREST, Japan Agency for Medical Research and Development)

Abstract

Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.

Suggested Citation

  • Junki Miyamoto & Miki Igarashi & Keita Watanabe & Shin-ichiro Karaki & Hiromi Mukouyama & Shigenobu Kishino & Xuan Li & Atsuhiko Ichimura & Junichiro Irie & Yukihiko Sugimoto & Tetsuya Mizutani & Tats, 2019. "Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11978-0
    DOI: 10.1038/s41467-019-11978-0
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    Cited by:

    1. Gabriel Lachance & Karine Robitaille & Jalal Laaraj & Nikunj Gevariya & Thibault V. Varin & Andrei Feldiorean & Fanny Gaignier & Isabelle Bourdeau Julien & Hui Wen Xu & Tarek Hallal & Jean-François Pe, 2024. "The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Marc Schoeler & Sandrine Ellero-Simatos & Till Birkner & Jordi Mayneris-Perxachs & Lisa Olsson & Harald Brolin & Ulrike Loeber & Jamie D. Kraft & Arnaud Polizzi & Marian Martí-Navas & Josep Puig & Ant, 2023. "The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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