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Feedforward prediction error signals during episodic memory retrieval

Author

Listed:
  • Rafi U. Haque

    (NINDS, National Institutes of Health)

  • Sara K. Inati

    (NINDS, National Institutes of Health)

  • Allan I. Levey

    (Emory University)

  • Kareem A. Zaghloul

    (NINDS, National Institutes of Health)

Abstract

Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for future experience within neocortical-medial temporal lobe circuits. When subsequent experiences violate these expectations, we find a 80–120 Hz prediction error signal that emerges in both visual association areas and the medial temporal lobe. Critically, this error signal emerges in visual association areas first and then propagates to the medial temporal lobe. This error signal is accompanied by alpha coherence between the two regions. Our data therefore suggest that internal models formed from episodic memories are generated throughout the visual hierarchy after just a single exposure, and that these internal models are then used for comparison with future experiences.

Suggested Citation

  • Rafi U. Haque & Sara K. Inati & Allan I. Levey & Kareem A. Zaghloul, 2020. "Feedforward prediction error signals during episodic memory retrieval," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19828-0
    DOI: 10.1038/s41467-020-19828-0
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    Cited by:

    1. Jan Weber & Anne-Kristin Solbakk & Alejandro O. Blenkmann & Anais Llorens & Ingrid Funderud & Sabine Leske & Pål Gunnar Larsson & Jugoslav Ivanovic & Robert T. Knight & Tor Endestad & Randolph F. Helf, 2024. "Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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