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Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Author

Listed:
  • Keundong Lee

    (University of California San Diego)

  • Angelique C. Paulk

    (Harvard Medical School
    Massachusetts General Hospital)

  • Yun Goo Ro

    (University of California San Diego)

  • Daniel R. Cleary

    (University of California San Diego
    University of California San Diego)

  • Karen J. Tonsfeldt

    (University of California San Diego
    University of California San Diego)

  • Yoav Kfir

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • John S. Pezaris

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • Youngbin Tchoe

    (University of California San Diego)

  • Jihwan Lee

    (University of California San Diego)

  • Andrew M. Bourhis

    (University of California San Diego)

  • Ritwik Vatsyayan

    (University of California San Diego)

  • Joel R. Martin

    (University of California San Diego)

  • Samantha M. Russman

    (University of California San Diego)

  • Jimmy C. Yang

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • Amy Baohan

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • R. Mark Richardson

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • Ziv M. Williams

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • Shelley I. Fried

    (Harvard Medical School
    Department of Neurosurgery, Massachusetts General Hospital)

  • U. Hoi Sang

    (University of California San Diego)

  • Ahmed M. Raslan

    (Oregon Health and Science University)

  • Sharona Ben-Haim

    (University of California San Diego)

  • Eric Halgren

    (University of California San Diego)

  • Sydney S. Cash

    (Harvard Medical School
    Massachusetts General Hospital)

  • Shadi. A. Dayeh

    (University of California San Diego)

Abstract

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.

Suggested Citation

  • Keundong Lee & Angelique C. Paulk & Yun Goo Ro & Daniel R. Cleary & Karen J. Tonsfeldt & Yoav Kfir & John S. Pezaris & Youngbin Tchoe & Jihwan Lee & Andrew M. Bourhis & Ritwik Vatsyayan & Joel R. Mart, 2024. "Flexible, scalable, high channel count stereo-electrode for recording in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-43727-9
    DOI: 10.1038/s41467-023-43727-9
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    References listed on IDEAS

    as
    1. Leigh R. Hochberg & Daniel Bacher & Beata Jarosiewicz & Nicolas Y. Masse & John D. Simeral & Joern Vogel & Sami Haddadin & Jie Liu & Sydney S. Cash & Patrick van der Smagt & John P. Donoghue, 2012. "Reach and grasp by people with tetraplegia using a neurally controlled robotic arm," Nature, Nature, vol. 485(7398), pages 372-375, May.
    2. James J. Jun & Nicholas A. Steinmetz & Joshua H. Siegle & Daniel J. Denman & Marius Bauza & Brian Barbarits & Albert K. Lee & Costas A. Anastassiou & Alexandru Andrei & Çağatay Aydın & Mladen Barbic &, 2017. "Fully integrated silicon probes for high-density recording of neural activity," Nature, Nature, vol. 551(7679), pages 232-236, November.
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