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Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation

Author

Listed:
  • Fan Li

    (University of Pittsburgh
    Center for Neural Basis of Cognition
    University of Pittsburgh)

  • Jazlyn Gallego

    (University of Pittsburgh
    Center for Neural Basis of Cognition)

  • Natasha N. Tirko

    (Pennsylvania State University)

  • Jenna Greaser

    (Actuated Medical)

  • Derek Bashe

    (Washington University in St. Louis)

  • Rudra Patel

    (University of Pittsburgh)

  • Eric Shaker

    (University of Pittsburgh)

  • Grace E. Valkenburg

    (University of Pittsburgh)

  • Alanoud S. Alsubhi

    (Actuated Medical)

  • Steven Wellman

    (Columbia University)

  • Vanshika Singh

    (University of Pittsburgh)

  • Camila Garcia Padilla

    (University of Pittsburgh
    Center for Neural Basis of Cognition)

  • Kyle W. Gheres

    (Actuated Medical)

  • John I. Broussard

    (Actuated Medical)

  • Roger Bagwell

    (Actuated Medical)

  • Maureen Mulvihill

    (Actuated Medical)

  • Takashi D. Y. Kozai

    (University of Pittsburgh
    Center for Neural Basis of Cognition
    University of Pittsburgh
    University of Pittsburgh)

Abstract

Microglia are important players in surveillance and repair of the brain. Implanting an electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the foreign body response, and opens the blood-brain barrier. These changes can impede intracortical brain-computer interfaces performance. Using two-photon imaging of implanted microelectrodes, we test the hypothesis that low-intensity pulsed ultrasound stimulation can reduce microglia-mediated neuroinflammation following the implantation of microelectrodes. In the first week of treatment, we found that low-intensity pulsed ultrasound stimulation increased microglia migration speed by 128%, enhanced microglia expansion area by 109%, and a reduction in microglial activation by 17%, indicating improved tissue healing and surveillance. Microglial coverage of the microelectrode was reduced by 50% and astrocytic scarring by 36% resulting in an increase in recording performance at chronic time. The data indicate that low-intensity pulsed ultrasound stimulation helps reduce the foreign body response around chronic intracortical microelectrodes.

Suggested Citation

  • Fan Li & Jazlyn Gallego & Natasha N. Tirko & Jenna Greaser & Derek Bashe & Rudra Patel & Eric Shaker & Grace E. Valkenburg & Alanoud S. Alsubhi & Steven Wellman & Vanshika Singh & Camila Garcia Padill, 2024. "Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49709-9
    DOI: 10.1038/s41467-024-49709-9
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