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A distinct neuronal ensemble of prelimbic cortex mediates spontaneous pain in rats with peripheral inflammation

Author

Listed:
  • Longyu Ma

    (Peking University)

  • Lupeng Yue

    (CAS Key Laboratory of Mental Health, Institute of Psychology
    University of Chinese Academy of Science)

  • Shuting Liu

    (Peking University)

  • Shi Xu

    (Peking University)

  • Jifu Tong

    (Peking University)

  • Xiaoyan Sun

    (Peking University)

  • Li Su

    (Peking University)

  • Shuang Cui

    (Peking University)

  • Feng-Yu Liu

    (Peking University)

  • You Wan

    (Peking University
    Peking University
    Beijing Life Science Academy)

  • Ming Yi

    (Peking University
    Peking University
    Medical Innovation Center (Taizhou) of Peking University)

Abstract

The absence of a comprehensive understanding of the neural basis of spontaneous pain limits the development of therapeutic strategies targeting this primary complaint of patients with chronic pain. Here we report a distinct neuronal ensemble within the prelimbic cortex which processes signals related to spontaneous pain in rats with chronic inflammatory pain. This neuronal ensemble specifically encodes spontaneous pain-related behaviors, independently of other locomotive and evoked behaviors. Activation of this neuronal ensemble elicits marked spontaneous pain-like behaviors and enhances nociceptive responses, whereas prolonged silencing of its activities alleviates spontaneous pain and promotes overall recovery from inflammatory pain. Notably, afferents from the primary somatosensory cortex and infralimbic cortex bidirectionally modulate the activities of the spontaneous pain-responsive prelimbic cortex neuronal ensemble and pain behaviors. These findings reveal the cortical basis of spontaneous pain at the neuronal level, highlighting a distinct neuronal ensemble within the prelimbic cortex and its associated pain-regulatory brain networks.

Suggested Citation

  • Longyu Ma & Lupeng Yue & Shuting Liu & Shi Xu & Jifu Tong & Xiaoyan Sun & Li Su & Shuang Cui & Feng-Yu Liu & You Wan & Ming Yi, 2024. "A distinct neuronal ensemble of prelimbic cortex mediates spontaneous pain in rats with peripheral inflammation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52243-3
    DOI: 10.1038/s41467-024-52243-3
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