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Zn/Pt dual-site single-atom driven difunctional superimposition-augmented sonosensitizer for sonodynamic therapy boosted ferroptosis of cancer

Author

Listed:
  • Ding Wen

    (Chinese Academy of Sciences
    University of Science and Technology of China)

  • Jing Feng

    (Chinese Academy of Sciences
    University of Science and Technology of China)

  • Ruiping Deng

    (Chinese Academy of Sciences)

  • Kai Li

    (Chinese Academy of Sciences)

  • Hongjie Zhang

    (Chinese Academy of Sciences
    University of Science and Technology of China
    Tsinghua University)

Abstract

Sonodynamic therapy (SDT) as a non-invasive antitumor strategy has been widely concerned. However, the rapid electron (e-) and hole (h+) recombination of traditional inorganic semiconductor sonosensitizers under ultrasonic (US) stimulation greatly limits the production of reactive oxygen species (ROS). Herein, we report a unique Zn/Pt dual-site single-atom driven difunctional superimposition-augmented TiO2-based sonosensitizer (Zn/Pt SATs). Initially, we verify through theoretical calculation that the strongly coupled Zn and Pt atoms can assist electron excitation at the atomic level by increasing electron conductivity and excitation efficiency under US, respectively, thus effectively improving the yield of ROS. Additionally, Zn/Pt SATs can significantly enhance ferroptosis by producing more ROS and sonoexcited holes under US stimuli. Therefore, the establishment of dual-site single-atom system represents an innovative strategy to enhance SDT in cancer model of female mice and provides a typical example for the development of inorganic sonosensitizer in the field of antitumor therapy.

Suggested Citation

  • Ding Wen & Jing Feng & Ruiping Deng & Kai Li & Hongjie Zhang, 2024. "Zn/Pt dual-site single-atom driven difunctional superimposition-augmented sonosensitizer for sonodynamic therapy boosted ferroptosis of cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53488-8
    DOI: 10.1038/s41467-024-53488-8
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    References listed on IDEAS

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    1. Chao Liang & Jiaen Xie & Shuangling Luo & Can Huang & Qianling Zhang & Huaiyi Huang & Pingyu Zhang, 2021. "A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    2. Fei Gong & Liang Cheng & Nailin Yang & Yuehan Gong & Yanwen Ni & Shang Bai & Xianwen Wang & Muchao Chen & Qian Chen & Zhuang Liu, 2020. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    3. Bijiang Geng & Jinyan Hu & Yuan Li & Shini Feng & Dengyu Pan & Lingyan Feng & Longxiang Shen, 2022. "Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Xiaoran Zhang & Xiaorong Zhu & Shuowen Bo & Chen Chen & Mengyi Qiu & Xiaoxiao Wei & Nihan He & Chao Xie & Wei Chen & Jianyun Zheng & Pinsong Chen & San Ping Jiang & Yafei Li & Qinghua Liu & Shuangyin , 2022. "Identifying and tailoring C–N coupling site for efficient urea synthesis over diatomic Fe–Ni catalyst," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
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