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Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy

Author

Listed:
  • Fei Gong

    (Soochow University)

  • Liang Cheng

    (Soochow University)

  • Nailin Yang

    (Soochow University)

  • Yuehan Gong

    (Soochow University)

  • Yanwen Ni

    (Soochow University)

  • Shang Bai

    (Soochow University)

  • Xianwen Wang

    (Soochow University)

  • Muchao Chen

    (Soochow University)

  • Qian Chen

    (Soochow University)

  • Zhuang Liu

    (Soochow University)

Abstract

Metal hydrides have been rarely used in biomedicine. Herein, we fabricate titanium hydride (TiH1.924) nanodots from its powder form via the liquid-phase exfoliation, and apply these metal hydride nanodots for effective cancer treatment. The liquid-phase exfoliation is an effective method to synthesize these metal hydride nanomaterials, and its efficiency is determined by the matching of surface energy between the solvent and the metal hydrides. The obtained TiH1.924 nanodots can produce reactive oxygen species (ROS) under ultrasound, presenting a highly efficient sono-sensitizing effect. Meanwhile, TiH1.924 nanodots with strong near-infrared (NIR) absorbance can serve as a robust photothermal agent. By using the mild photothermal effect to enhance intra-tumoral blood flow and improve tumor oxygenation, a remarkable synergistic therapeutic effect is achieved in the combined photothermal-sonodynamic therapy. Importantly, most of these TiH1.924 nanodots can be cleared out from the body. This work presents the promises of functional metal hydride nanomaterials for biomedical applications.

Suggested Citation

  • Fei Gong & Liang Cheng & Nailin Yang & Yuehan Gong & Yanwen Ni & Shang Bai & Xianwen Wang & Muchao Chen & Qian Chen & Zhuang Liu, 2020. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17485-x
    DOI: 10.1038/s41467-020-17485-x
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    Cited by:

    1. Yongjiang Li & Wei Chen & Yong Kang & Xueyan Zhen & Zhuoming Zhou & Chuang Liu & Shuying Chen & Xiangang Huang & Hai-Jun Liu & Seyoung Koo & Na Kong & Xiaoyuan Ji & Tian Xie & Wei Tao, 2023. "Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Bijiang Geng & Jinyan Hu & Yuan Li & Shini Feng & Dengyu Pan & Lingyan Feng & Longxiang Shen, 2022. "Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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