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Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Author

Listed:
  • Bijiang Geng

    (Shanghai University)

  • Jinyan Hu

    (Shanghai University)

  • Yuan Li

    (Shanghai University)

  • Shini Feng

    (Shanghai University)

  • Dengyu Pan

    (Shanghai University)

  • Lingyan Feng

    (Shanghai University)

  • Longxiang Shen

    (Shanghai Jiao Tong University affiliated Sixth People’s Hospital)

Abstract

Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation of e−–h+ pairs and fast transfer to reaction sites. Importantly, the cancer-specific targeting and high-level intratumor enrichment of the theranostic CDs are achieved by cancer cell membrane encapsulation for precision SDT with complete eradication of solid tumors by single injection and single irradiation. These results will open up a promising approach to engineer phosphorescent materials with long-lived triplet excited states for sonodynamic precision tumor therapy.

Suggested Citation

  • Bijiang Geng & Jinyan Hu & Yuan Li & Shini Feng & Dengyu Pan & Lingyan Feng & Longxiang Shen, 2022. "Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33474-8
    DOI: 10.1038/s41467-022-33474-8
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    References listed on IDEAS

    as
    1. Fei Gong & Liang Cheng & Nailin Yang & Yuehan Gong & Yanwen Ni & Shang Bai & Xianwen Wang & Muchao Chen & Qian Chen & Zhuang Liu, 2020. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    2. Yuqiong Sun & Shuting Liu & Luyi Sun & Shuangshuang Wu & Guangqi Hu & Xiaoliang Pang & Andrew T. Smith & Chaofan Hu & Songshan Zeng & Weixing Wang & Yingliang Liu & Mingtao Zheng, 2020. "Ultralong lifetime and efficient room temperature phosphorescent carbon dots through multi-confinement structure design," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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    Cited by:

    1. Ding Wen & Jing Feng & Ruiping Deng & Kai Li & Hongjie Zhang, 2024. "Zn/Pt dual-site single-atom driven difunctional superimposition-augmented sonosensitizer for sonodynamic therapy boosted ferroptosis of cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Guang-Song Zheng & Cheng-Long Shen & Chun-Yao Niu & Qing Lou & Tian-Ci Jiang & Peng-Fei Li & Xiao-Jing Shi & Run-Wei Song & Yuan Deng & Chao-Fan Lv & Kai-Kai Liu & Jin-Hao Zang & Zhe Cheng & Lin Dong , 2024. "Photooxidation triggered ultralong afterglow in carbon nanodots," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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