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Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy

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  • Enrico Orsi

    (Technical University of Denmark)

  • Pablo Ivan Nikel

    (Technical University of Denmark)

  • Lars Keld Nielsen

    (Technical University of Denmark
    The University of Queensland)

  • Stefano Donati

    (Technical University of Denmark)

Abstract

A true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO2, formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To render C1-based biomanufacturing cost-competitive, we must adapt microbial metabolism to perform chemical conversions at high rates and yields. To this end, the biotechnology community has undertaken two (seemingly opposing) paths: optimizing natural C1-trophic microorganisms versus engineering synthetic C1-assimilation de novo in model microorganisms. Here, we pose how these approaches can instead create synergies for strengthening the competitiveness of C1-based biomanufacturing as a whole.

Suggested Citation

  • Enrico Orsi & Pablo Ivan Nikel & Lars Keld Nielsen & Stefano Donati, 2023. "Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42166-w
    DOI: 10.1038/s41467-023-42166-w
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