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Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress

Author

Listed:
  • Ling Ye

    (Southern Medical University)

  • Yuanlong Hou

    (China Pharmaceutical University
    Shenzhen Luohu People’s Hospital)

  • Wanyu Hu

    (Southern Medical University)

  • Hongmei Wang

    (Southern Medical University)

  • Ruopeng Yang

    (Southern Medical University)

  • Qihan Zhang

    (Southern Medical University)

  • Qiaoli Feng

    (Southern Medical University)

  • Xiao Zheng

    (China Pharmaceutical University)

  • Guangyu Yao

    (Southern Medical University)

  • Haiping Hao

    (China Pharmaceutical University)

Abstract

Chronic stress is a known risk factor for breast cancer, yet the underlying mechanisms are unclear. This study explores the potential involvement of microbial and metabolic signals in chronic stress-promoted breast cancer progression, revealing that reduced abundances of Blautia and its metabolite acetate may contribute to this process. Treatment with Blautia and acetate increases antitumor responses of CD8+ T cells and reverses stress-promoted breast cancer progression in female mice. Patients with depression exhibit lower abundances of Blautia and acetate, and breast cancer female patients with depression display lower abundances of acetate, decreased numbers of tumor-infiltrating CD8+ T cells, and an increased risk of metastasis. These results suggest that Blautia-derived acetate plays a crucial role in modulating the immune response to breast cancer, and its reduction may contribute to chronic stress-promoted cancer progression. Our findings advance the understanding of microbial and metabolic signals implicated in cancer in patients with depression and may provide therapeutic options for female patients with breast cancer and depression.

Suggested Citation

  • Ling Ye & Yuanlong Hou & Wanyu Hu & Hongmei Wang & Ruopeng Yang & Qihan Zhang & Qiaoli Feng & Xiao Zheng & Guangyu Yao & Haiping Hao, 2023. "Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41817-2
    DOI: 10.1038/s41467-023-41817-2
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    2. Nicholas Arpaia & Clarissa Campbell & Xiying Fan & Stanislav Dikiy & Joris van der Veeken & Paul deRoos & Hui Liu & Justin R. Cross & Klaus Pfeffer & Paul J. Coffer & Alexander Y. Rudensky, 2013. "Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation," Nature, Nature, vol. 504(7480), pages 451-455, December.
    3. Christoph A. Thaiss & Niv Zmora & Maayan Levy & Eran Elinav, 2016. "The microbiome and innate immunity," Nature, Nature, vol. 535(7610), pages 65-74, July.
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