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Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution

Author

Listed:
  • Alexandre Soares Ferreira-Junior

    (Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Sao Jose do Rio Preto 15054-000, Brazil)

  • Tais Fernanda Borgonovi

    (Food Engineering and Technology Department, Sao Paulo State University (UNESP), Sao Jose do Rio Preto 15054-000, Brazil)

  • Larissa Vedovato Vilela De Salis

    (Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Sao Jose do Rio Preto 15054-000, Brazil)

  • Aline Zazeri Leite

    (Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Sao Jose do Rio Preto 15054-000, Brazil)

  • Amanda Soares Dantas

    (Barretos Board of Health, Emergency Care Unit, Barretos 14780-900, Brazil)

  • Guilherme Vedovato Vilela De Salis

    (Barretos Board of Health, Emergency Care Unit, Barretos 14780-900, Brazil)

  • Giuliano Netto Flores Cruz

    (BiomeHub Research and Development, Florianopolis 88054-700, Brazil)

  • Luiz Felipe Valter De Oliveira

    (BiomeHub Research and Development, Florianopolis 88054-700, Brazil)

  • Eleni Gomes

    (Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Sao Jose do Rio Preto 15054-000, Brazil)

  • Ana Lúcia Barretto Penna

    (Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Sao Jose do Rio Preto 15054-000, Brazil
    Food Engineering and Technology Department, Sao Paulo State University (UNESP), Sao Jose do Rio Preto 15054-000, Brazil)

  • Gislane Lelis Vilela De Oliveira

    (Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Sao Jose do Rio Preto 15054-000, Brazil
    Food Engineering and Technology Department, Sao Paulo State University (UNESP), Sao Jose do Rio Preto 15054-000, Brazil)

Abstract

The intestinal microbiota plays an important role in the immune response against viral infections, modulating both innate and adaptive immune responses. The cytokine storm is associated with COVID-19 severity, and the patient’s immune status is influenced by the intestinal microbiota in a gut-lung bidirectional interaction. In this study, we evaluate the intestinal microbiota of Brazilian patients in different post-COVID-19 periods, and correlate this with clinical data and the antibiotic therapy used during the acute phase. DNA extracted from stool samples was sequenced and total anti-SARS-CoV-2 antibodies and C-reactive protein were quantified. Compared with controls, there were significant differences in the microbiota diversity in post-COVID-19 patients, suggesting an intestinal dysbiosis even several months after acute disease resolution. Additionally, we detected some genera possibly associated with the post-COVID-19 dysbiosis, including Desulfovibrio , Haemophillus , Dialister , and Prevotella , in addition to decreased beneficial microbes, associated with antibiotic-induced dysbiosis, such as Bifidobacterium and Akkermansia . Therefore, our hypothesis is that dysbiosis and the indiscriminate use of antibiotics during the pandemic may be associated with post-COVID-19 clinical manifestations. In our study, 39% ( n = 58) of patients reported symptoms, including fatigue, dyspnea, myalgia, alopecia, anxiety, memory loss, and depression. These data suggest that microbiota modulation may represent a target for recovery from acute COVID-19 and a therapeutic approach for post-COVID-19 sequelae.

Suggested Citation

  • Alexandre Soares Ferreira-Junior & Tais Fernanda Borgonovi & Larissa Vedovato Vilela De Salis & Aline Zazeri Leite & Amanda Soares Dantas & Guilherme Vedovato Vilela De Salis & Giuliano Netto Flores C, 2022. "Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10189-:d:890257
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    References listed on IDEAS

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    1. Kenya Honda & Dan R. Littman, 2016. "The microbiota in adaptive immune homeostasis and disease," Nature, Nature, vol. 535(7610), pages 75-84, July.
    2. Christoph A. Thaiss & Niv Zmora & Maayan Levy & Eran Elinav, 2016. "The microbiome and innate immunity," Nature, Nature, vol. 535(7610), pages 65-74, July.
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