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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Author

Listed:
  • Nicholas Arpaia

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

  • Clarissa Campbell

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

  • Xiying Fan

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

  • Stanislav Dikiy

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

  • Joris van der Veeken

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

  • Paul deRoos

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

  • Hui Liu

    (Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan-Kettering Cancer Center)

  • Justin R. Cross

    (Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan-Kettering Cancer Center)

  • Klaus Pfeffer

    (Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Duesseldorf, Duesseldorf 40225, Germany)

  • Paul J. Coffer

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center
    University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands)

  • Alexander Y. Rudensky

    (Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
    Immunology Program, Memorial Sloan-Kettering Cancer Center)

Abstract

In mice, provision of butyrate—a short-chain fatty acid produced by commensal microorganisms during starch fermentation—facilitates extrathymic generation and differentiation of Foxp3+ regulatory T cells, demonstrating that metabolic by-products are sensed by cells of the immune system and affect the balance between pro- and anti-inflammatory cells.

Suggested Citation

  • Nicholas Arpaia & Clarissa Campbell & Xiying Fan & Stanislav Dikiy & Joris van der Veeken & Paul deRoos & Hui Liu & Justin R. Cross & Klaus Pfeffer & Paul J. Coffer & Alexander Y. Rudensky, 2013. "Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation," Nature, Nature, vol. 504(7480), pages 451-455, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12726
    DOI: 10.1038/nature12726
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    1. Felipe Papa Pellizoni & Aline Zazeri Leite & Nathália de Campos Rodrigues & Marcelo Jordão Ubaiz & Marina Ignácio Gonzaga & Nauyta Naomi Campos Takaoka & Vânia Sammartino Mariano & Wellington Pine Omo, 2021. "Detection of Dysbiosis and Increased Intestinal Permeability in Brazilian Patients with Relapsing–Remitting Multiple Sclerosis," IJERPH, MDPI, vol. 18(9), pages 1-17, April.
    2. Ling Ye & Yuanlong Hou & Wanyu Hu & Hongmei Wang & Ruopeng Yang & Qihan Zhang & Qiaoli Feng & Xiao Zheng & Guangyu Yao & Haiping Hao, 2023. "Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Andrew C. Tolonen & Nicholas Beauchemin & Charlie Bayne & Lingyao Li & Jie Tan & Jackson Lee & Brian M. Meehan & Jeffrey Meisner & Yves Millet & Gabrielle LeBlanc & Robert Kottler & Erdmann Rapp & Chr, 2022. "Synthetic glycans control gut microbiome structure and mitigate colitis in mice," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Pasquale Comberiati & Maria Di Cicco & Francesco Paravati & Umberto Pelosi & Alessandro Di Gangi & Stefania Arasi & Simona Barni & Davide Caimmi & Carla Mastrorilli & Amelia Licari & Fernanda Chiera, 2021. "The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis," IJERPH, MDPI, vol. 18(22), pages 1-20, November.
    5. Mitsuko L. Yamamoto & Robert H. Schiestl, 2014. "Lymphoma Caused by Intestinal Microbiota," IJERPH, MDPI, vol. 11(9), pages 1-12, September.
    6. Anna-Lena Geiselhöringer & Daphne Kolland & Arisha Johanna Patt & Linda Hammann & Amelie Köhler & Luisa Kreft & Nina Wichmann & Miriam Hils & Christiane Ruedl & Marc Riemann & Tilo Biedermann & David , 2024. "Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Natsuko Tabata & Mai Tsukada & Kozue Kubo & Yuri Inoue & Reiko Miroku & Fumihiko Odashima & Koichiro Shiratori & Takashi Sekiya & Shintaro Sengoku & Hideaki Shiroyama & Hiromichi Kimura, 2022. "Living Lab for Citizens’ Wellness: A Case of Maintaining and Improving a Healthy Diet under the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(3), pages 1-17, January.
    8. JangKeun Kim & Braden T. Tierney & Eliah G. Overbey & Ezequiel Dantas & Matias Fuentealba & Jiwoon Park & S. Anand Narayanan & Fei Wu & Deena Najjar & Christopher R. Chin & Cem Meydan & Conor Loy & Be, 2024. "Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    9. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.

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