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The microbiome and innate immunity

Author

Listed:
  • Christoph A. Thaiss

    (Weizmann Institute of Science)

  • Niv Zmora

    (Weizmann Institute of Science
    Tel Aviv Sourasky Medical Center
    Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center)

  • Maayan Levy

    (Weizmann Institute of Science)

  • Eran Elinav

    (Weizmann Institute of Science)

Abstract

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host–microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.

Suggested Citation

  • Christoph A. Thaiss & Niv Zmora & Maayan Levy & Eran Elinav, 2016. "The microbiome and innate immunity," Nature, Nature, vol. 535(7610), pages 65-74, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18847
    DOI: 10.1038/nature18847
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    Cited by:

    1. Alexandre Soares Ferreira-Junior & Tais Fernanda Borgonovi & Larissa Vedovato Vilela De Salis & Aline Zazeri Leite & Amanda Soares Dantas & Guilherme Vedovato Vilela De Salis & Giuliano Netto Flores C, 2022. "Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    2. Sang Chul Park & Il-Ho Park & Joong Seob Lee & Sung Min Park & Sung Hun Kang & Seok-Min Hong & Soo-Hwan Byun & Yong Gi Jung & Seok Jin Hong, 2021. "Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis," IJERPH, MDPI, vol. 18(18), pages 1-16, September.
    3. Ling Ye & Yuanlong Hou & Wanyu Hu & Hongmei Wang & Ruopeng Yang & Qihan Zhang & Qiaoli Feng & Xiao Zheng & Guangyu Yao & Haiping Hao, 2023. "Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Corina Verónica Sasso & Leila Ester Zyla & Flavia Alejandra Bruna & Virginia Pistone Creydt & Constanza Matilde López Fontana & Rubén Walter Carón & Flavia Eliana Santiano & Fiorella Campo Verde A, 2019. "High Intake of Maternal Milk Prevents the Development of Mammary Cancer in Pups Maintaining Elevated Ingestion of Saturated Fat," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 16(2), pages 1-9, March.
    5. Carlotta Suardi & Emanuela Cazzaniga & Stephanie Graci & Dario Dongo & Paola Palestini, 2021. "Link between Viral Infections, Immune System, Inflammation and Diet," IJERPH, MDPI, vol. 18(5), pages 1-13, March.
    6. Kai Markus Schneider & Antje Mohs & Wenfang Gui & Eric J. C. Galvez & Lena Susanna Candels & Lisa Hoenicke & Uthayakumar Muthukumarasamy & Christian H. Holland & Carsten Elfers & Konrad Kilic & Caroli, 2022. "Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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