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Decoupling of brain function from structure reveals regional behavioral specialization in humans

Author

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  • Maria Giulia Preti

    (École Polytechnique Fédérale de Lausanne (EPFL)
    University of Geneva)

  • Dimitri Van De Ville

    (École Polytechnique Fédérale de Lausanne (EPFL)
    University of Geneva)

Abstract

The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected areas can be expected higher. However, the degree to which brain function is bound by the underlying wiring diagram remains a complex question that has been only partially answered. Here, we introduce the structural-decoupling index to quantify the coupling strength between structure and function, and we reveal a macroscale gradient from brain regions more strongly coupled, to regions more strongly decoupled, than expected by realistic surrogate data. This gradient spans behavioral domains from lower-level sensory function to high-level cognitive ones and shows for the first time that the strength of structure-function coupling is spatially varying in line with evidence derived from other modalities, such as functional connectivity, gene expression, microstructural properties and temporal hierarchy.

Suggested Citation

  • Maria Giulia Preti & Dimitri Van De Ville, 2019. "Decoupling of brain function from structure reveals regional behavioral specialization in humans," Nature Communications, Nature, vol. 10(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12765-7
    DOI: 10.1038/s41467-019-12765-7
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    Cited by:

    1. Jie Xia & Cirong Liu & Jiao Li & Yao Meng & Siqi Yang & Huafu Chen & Wei Liao, 2024. "Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Andrea I. Luppi & Helena M. Gellersen & Zhen-Qi Liu & Alexander R. D. Peattie & Anne E. Manktelow & Ram Adapa & Adrian M. Owen & Lorina Naci & David K. Menon & Stavros I. Dimitriadis & Emmanuel A. Sta, 2024. "Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    3. Marco Aqil & Selen Atasoy & Morten L Kringelbach & Rikkert Hindriks, 2021. "Graph neural fields: A framework for spatiotemporal dynamical models on the human connectome," PLOS Computational Biology, Public Library of Science, vol. 17(1), pages 1-29, January.
    4. Panagiotis Fotiadis & Matthew Cieslak & Xiaosong He & Lorenzo Caciagli & Mathieu Ouellet & Theodore D. Satterthwaite & Russell T. Shinohara & Dani S. Bassett, 2023. "Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Yaqian Yang & Zhiming Zheng & Longzhao Liu & Hongwei Zheng & Yi Zhen & Yi Zheng & Xin Wang & Shaoting Tang, 2023. "Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Evan Collins & Omar Chishti & Sami Obaid & Hari McGrath & Alex King & Xilin Shen & Jagriti Arora & Xenophon Papademetris & R. Todd Constable & Dennis D. Spencer & Hitten P. Zaveri, 2024. "Mapping the structure-function relationship along macroscale gradients in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Alessandra Griffa & Mathieu Mach & Julien Dedelley & Daniel Gutierrez-Barragan & Alessandro Gozzi & Gilles Allali & Joanes Grandjean & Dimitri Ville & Enrico Amico, 2023. "Evidence for increased parallel information transmission in human brain networks compared to macaques and male mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    8. Andrea I. Luppi & Lynn Uhrig & Jordy Tasserie & Camilo M. Signorelli & Emmanuel A. Stamatakis & Alain Destexhe & Bechir Jarraya & Rodrigo Cofre, 2024. "Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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