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Heritability and interindividual variability of regional structure-function coupling

Author

Listed:
  • Zijin Gu

    (Cornell University)

  • Keith Wakefield Jamison

    (Weill Cornell Medicine)

  • Mert Rory Sabuncu

    (Cornell University
    Weill Cornell Medicine)

  • Amy Kuceyeski

    (Weill Cornell Medicine)

Abstract

White matter structural connections are likely to support flow of functional activation or functional connectivity. While the relationship between structural and functional connectivity profiles, here called SC-FC coupling, has been studied on a whole-brain, global level, few studies have investigated this relationship at a regional scale. Here we quantify regional SC-FC coupling in healthy young adults using diffusion-weighted MRI and resting-state functional MRI data from the Human Connectome Project and study how SC-FC coupling may be heritable and varies between individuals. We show that regional SC-FC coupling strength varies widely across brain regions, but was strongest in highly structurally connected visual and subcortical areas. We also show interindividual regional differences based on age, sex and composite cognitive scores, and that SC-FC coupling was highly heritable within certain networks. These results suggest regional structure-function coupling is an idiosyncratic feature of brain organisation that may be influenced by genetic factors.

Suggested Citation

  • Zijin Gu & Keith Wakefield Jamison & Mert Rory Sabuncu & Amy Kuceyeski, 2021. "Heritability and interindividual variability of regional structure-function coupling," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25184-4
    DOI: 10.1038/s41467-021-25184-4
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    Cited by:

    1. Loïc Labache & Tian Ge & B. T. Thomas Yeo & Avram J. Holmes, 2023. "Language network lateralization is reflected throughout the macroscale functional organization of cortex," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Svenja Küchenhoff & Şeyma Bayrak & Rachel G. Zsido & Amin Saberi & Boris C. Bernhardt & Susanne Weis & H. Lina Schaare & Julia Sacher & Simon Eickhoff & Sofie L. Valk, 2024. "Relating sex-bias in human cortical and hippocampal microstructure to sex hormones," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Panagiotis Fotiadis & Matthew Cieslak & Xiaosong He & Lorenzo Caciagli & Mathieu Ouellet & Theodore D. Satterthwaite & Russell T. Shinohara & Dani S. Bassett, 2023. "Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Yaqian Yang & Zhiming Zheng & Longzhao Liu & Hongwei Zheng & Yi Zhen & Yi Zheng & Xin Wang & Shaoting Tang, 2023. "Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Sofie L. Valk & Ting Xu & Casey Paquola & Bo-yong Park & Richard A. I. Bethlehem & Reinder Vos de Wael & Jessica Royer & Shahrzad Kharabian Masouleh & Şeyma Bayrak & Peter Kochunov & B. T. Thomas Yeo , 2022. "Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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