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Myelination and support of axonal integrity by glia

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  • Klaus-Armin Nave

    (Max Planck Institute of Experimental Medicine)

Abstract

The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain. Cell biology and mouse genetics have provided insight into axon–glia signalling and the molecular architecture of the myelin sheath. Glial cells that myelinate axons were found to have a dual role by also supporting the long-term integrity of those axons. This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders.

Suggested Citation

  • Klaus-Armin Nave, 2010. "Myelination and support of axonal integrity by glia," Nature, Nature, vol. 468(7321), pages 244-252, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09614
    DOI: 10.1038/nature09614
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    Cited by:

    1. Panagiotis Fotiadis & Matthew Cieslak & Xiaosong He & Lorenzo Caciagli & Mathieu Ouellet & Theodore D. Satterthwaite & Russell T. Shinohara & Dani S. Bassett, 2023. "Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Alberto Lazari & Piergiorgio Salvan & Lennart Verhagen & Michiel Cottaar & Daniel Papp & Olof Jens van der Werf & Bronwyn Gavine & James Kolasinski & Matthew Webster & Charlotte J. Stagg & Matthew F. , 2022. "A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Yongwoo Kwon & Jin Hee Hong & Sungsam Kang & Hojun Lee & Yonghyeon Jo & Ki Hean Kim & Seokchan Yoon & Wonshik Choi, 2023. "Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    4. Quiroz-González, Salvador & Rodríguez-Torres, Erika Elizabeth & Segura-Alegría, Bertha & Pereira-Venegas, Javier & Lopez-Gomez, Rosa Estela & Jiménez-Estrada, Ismael, 2016. "Detrended fluctuation analysis of compound action potentials re-corded in the cutaneous nerves of diabetic rats," Chaos, Solitons & Fractals, Elsevier, vol. 83(C), pages 223-233.
    5. Frederic Fiore & Khaleel Alhalaseh & Ram R. Dereddi & Felipe Bodaleo Torres & Ilknur Çoban & Ali Harb & Amit Agarwal, 2023. "Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-25, December.

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