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Relating sex-bias in human cortical and hippocampal microstructure to sex hormones

Author

Listed:
  • Svenja Küchenhoff

    (Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences
    Heinrich Heine University Düsseldorf
    University of Oxford)

  • Şeyma Bayrak

    (Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences)

  • Rachel G. Zsido

    (Max Planck Institute for Human Cognitive and Brain Sciences
    Harvard Medical School)

  • Amin Saberi

    (Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences
    Heinrich Heine University Düsseldorf)

  • Boris C. Bernhardt

    (Montreal Neurological Institute)

  • Susanne Weis

    (Research Centre Jülich
    Heinrich Heine University Düsseldorf)

  • H. Lina Schaare

    (Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences)

  • Julia Sacher

    (Medical Faculty & University Hospital Leipzig)

  • Simon Eickhoff

    (Research Centre Jülich
    Heinrich Heine University Düsseldorf)

  • Sofie L. Valk

    (Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences
    Heinrich Heine University Düsseldorf)

Abstract

Determining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment of brain-related disorders. So far, studies on sex-bias in brain structure predominantly focus on macro-scale measures, and often ignore factors determining this bias. Here we study sex-bias in cortical and hippocampal microstructure in relation to sex hormones. Investigating quantitative intracortical profiling in-vivo using the T1w/T2w ratio in 1093 healthy females and males of the cross-sectional Human Connectome Project young adult sample, we find that regional cortical and hippocampal microstructure differs between males and females and that the effect size of this sex-bias varies depending on self-reported hormonal status in females. Microstructural sex-bias and expression of sex hormone genes, based on an independent post-mortem sample, are spatially coupled. Lastly, sex-bias is most pronounced in paralimbic areas, with low laminar complexity, which are predicted to be most plastic based on their cytoarchitectural properties. Albeit correlative, our study underscores the importance of incorporating sex hormone variables into the investigation of brain structure and plasticity.

Suggested Citation

  • Svenja Küchenhoff & Şeyma Bayrak & Rachel G. Zsido & Amin Saberi & Boris C. Bernhardt & Susanne Weis & H. Lina Schaare & Julia Sacher & Simon Eickhoff & Sofie L. Valk, 2024. "Relating sex-bias in human cortical and hippocampal microstructure to sex hormones," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51459-7
    DOI: 10.1038/s41467-024-51459-7
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    1. Zijin Gu & Keith Wakefield Jamison & Mert Rory Sabuncu & Amy Kuceyeski, 2021. "Heritability and interindividual variability of regional structure-function coupling," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. B. Gegenhuber & M. V. Wu & R. Bronstein & J. Tollkuhn, 2022. "Gene regulation by gonadal hormone receptors underlies brain sex differences," Nature, Nature, vol. 606(7912), pages 153-159, June.
    3. Michael J. Hawrylycz & Ed S. Lein & Angela L. Guillozet-Bongaarts & Elaine H. Shen & Lydia Ng & Jeremy A. Miller & Louie N. van de Lagemaat & Kimberly A. Smith & Amanda Ebbert & Zackery L. Riley & Chr, 2012. "An anatomically comprehensive atlas of the adult human brain transcriptome," Nature, Nature, vol. 489(7416), pages 391-399, September.
    4. Casey Paquola & Reinder Vos De Wael & Konrad Wagstyl & Richard A I Bethlehem & Seok-Jun Hong & Jakob Seidlitz & Edward T Bullmore & Alan C Evans & Bratislav Misic & Daniel S Margulies & Jonathan Small, 2019. "Microstructural and functional gradients are increasingly dissociated in transmodal cortices," PLOS Biology, Public Library of Science, vol. 17(5), pages 1-28, May.
    5. Sofie L. Valk & Ting Xu & Casey Paquola & Bo-yong Park & Richard A. I. Bethlehem & Reinder Vos de Wael & Jessica Royer & Shahrzad Kharabian Masouleh & Şeyma Bayrak & Peter Kochunov & B. T. Thomas Yeo , 2022. "Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Lily R. Qiu & Darren J. Fernandes & Kamila U. Szulc-Lerch & Jun Dazai & Brian J. Nieman & Daniel H. Turnbull & Jane A. Foster & Mark R. Palmert & Jason P. Lerch, 2018. "Mouse MRI shows brain areas relatively larger in males emerge before those larger in females," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    7. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
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