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Gut microbiota Turicibacter strains differentially modify bile acids and host lipids

Author

Listed:
  • Jonathan B. Lynch

    (University of California, Los Angeles
    Johns Hopkins University School of Medicine)

  • Erika L. Gonzalez

    (University of California, Los Angeles)

  • Kayli Choy

    (University of California, Los Angeles)

  • Kym F. Faull

    (University of California, Los Angeles
    University of California, Los Angeles
    University of California, Los Angeles)

  • Talia Jewell

    (Isolation Bio)

  • Abelardo Arellano

    (Isolation Bio)

  • Jennifer Liang

    (Isolation Bio)

  • Kristie B. Yu

    (University of California, Los Angeles)

  • Jorge Paramo

    (University of California, Los Angeles)

  • Elaine Y. Hsiao

    (University of California, Los Angeles)

Abstract

Bacteria from the Turicibacter genus are prominent members of the mammalian gut microbiota and correlate with alterations in dietary fat and body weight, but the specific connections between these symbionts and host physiology are poorly understood. To address this knowledge gap, we characterize a diverse set of mouse- and human-derived Turicibacter isolates, and find they group into clades that differ in their transformations of specific bile acids. We identify Turicibacter bile salt hydrolases that confer strain-specific differences in bile deconjugation. Using male and female gnotobiotic mice, we find colonization with individual Turicibacter strains leads to changes in host bile acid profiles, generally aligning with those produced in vitro. Further, colonizing mice with another bacterium exogenously expressing bile-modifying genes from Turicibacter strains decreases serum cholesterol, triglycerides, and adipose tissue mass. This identifies genes that enable Turicibacter strains to modify host bile acids and lipid metabolism, and positions Turicibacter bacteria as modulators of host fat biology.

Suggested Citation

  • Jonathan B. Lynch & Erika L. Gonzalez & Kayli Choy & Kym F. Faull & Talia Jewell & Abelardo Arellano & Jennifer Liang & Kristie B. Yu & Jorge Paramo & Elaine Y. Hsiao, 2023. "Gut microbiota Turicibacter strains differentially modify bile acids and host lipids," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39403-7
    DOI: 10.1038/s41467-023-39403-7
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