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Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Author

Listed:
  • Matthew A. Jackson

    (King’s College London
    University of Oxford)

  • Serena Verdi

    (King’s College London)

  • Maria-Emanuela Maxan

    (King’s College Hospital Foundation Trust)

  • Cheol Min Shin

    (King’s College London
    Seoul National University Bundang Hospital)

  • Jonas Zierer

    (King’s College London
    Helmholtz Zentrum München)

  • Ruth C. E. Bowyer

    (King’s College London)

  • Tiphaine Martin

    (King’s College London
    Icahn School of Medicine at Mount Sinai)

  • Frances M. K. Williams

    (King’s College London)

  • Cristina Menni

    (King’s College London)

  • Jordana T. Bell

    (King’s College London)

  • Tim D. Spector

    (King’s College London)

  • Claire J. Steves

    (King’s College London
    King’s College Hospital Foundation Trust)

Abstract

The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.

Suggested Citation

  • Matthew A. Jackson & Serena Verdi & Maria-Emanuela Maxan & Cheol Min Shin & Jonas Zierer & Ruth C. E. Bowyer & Tiphaine Martin & Frances M. K. Williams & Cristina Menni & Jordana T. Bell & Tim D. Spec, 2018. "Gut microbiota associations with common diseases and prescription medications in a population-based cohort," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05184-7
    DOI: 10.1038/s41467-018-05184-7
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    Cited by:

    1. Tianqun Lang & Runqi Zhu & Xiao Zhu & Wenlu Yan & Yu Li & Yihui Zhai & Ting Wu & Xin Huang & Qi Yin & Yaping Li, 2023. "Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Oliver Aasmets & Kertu Liis Krigul & Kreete Lüll & Andres Metspalu & Elin Org, 2022. "Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohort," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Yadid M. Algavi & Elhanan Borenstein, 2023. "A data-driven approach for predicting the impact of drugs on the human microbiome," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Doris Vandeputte & Lindsey Commer & Raul Y. Tito & Gunter Kathagen & João Sabino & Séverine Vermeire & Karoline Faust & Jeroen Raes, 2021. "Temporal variability in quantitative human gut microbiome profiles and implications for clinical research," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Courtney Hoskinson & Darlene L. Y. Dai & Kate L. Bel & Allan B. Becker & Theo J. Moraes & Piushkumar J. Mandhane & B. Brett Finlay & Elinor Simons & Anita L. Kozyrskyj & Meghan B. Azad & Padmaja Subba, 2023. "Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Jonathan B. Lynch & Erika L. Gonzalez & Kayli Choy & Kym F. Faull & Talia Jewell & Abelardo Arellano & Jennifer Liang & Kristie B. Yu & Jorge Paramo & Elaine Y. Hsiao, 2023. "Gut microbiota Turicibacter strains differentially modify bile acids and host lipids," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Louise Grahnemo & Maria Nethander & Eivind Coward & Maiken Elvestad Gabrielsen & Satya Sree & Jean-Marc Billod & Klara Sjögren & Lars Engstrand & Koen F. Dekkers & Tove Fall & Arnulf Langhammer & Kris, 2023. "Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    8. Joonatan Palmu & Leo Lahti & Teemu Niiranen, 2021. "Targeting Gut Microbiota to Treat Hypertension: A Systematic Review," IJERPH, MDPI, vol. 18(3), pages 1-14, January.

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