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A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Author

Listed:
  • Jian Zhang

    (Ben May Department for Cancer Research)

  • Yongjun Zheng

    (East China University of Science & Technology
    Burns Center of Changhai Hospital)

  • Jimmy Lee

    (Ben May Department for Cancer Research)

  • Jieyu Hua

    (East China University of Science & Technology)

  • Shilong Li

    (Ben May Department for Cancer Research)

  • Ananth Panchamukhi

    (Ben May Department for Cancer Research)

  • Jiping Yue

    (Ben May Department for Cancer Research)

  • Xuewen Gou

    (Ben May Department for Cancer Research)

  • Zhaofan Xia

    (Burns Center of Changhai Hospital)

  • Linyong Zhu

    (East China University of Science & Technology)

  • Xiaoyang Wu

    (Ben May Department for Cancer Research)

Abstract

Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair.

Suggested Citation

  • Jian Zhang & Yongjun Zheng & Jimmy Lee & Jieyu Hua & Shilong Li & Ananth Panchamukhi & Jiping Yue & Xuewen Gou & Zhaofan Xia & Linyong Zhu & Xiaoyang Wu, 2021. "A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21964-0
    DOI: 10.1038/s41467-021-21964-0
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    Cited by:

    1. Yue Zhao & Shanliang Song & Dongdong Wang & He Liu & Junmin Zhang & Zuhao Li & Jincheng Wang & Xiangzhong Ren & Yanli Zhao, 2022. "Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Ran Yang & Xu Zhang & Binggang Chen & Qiuyan Yan & Jinghua Yin & Shifang Luan, 2023. "Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Hailei Zhang & Boyan Tang & Bo Zhang & Kai Huang & Shanshan Li & Yuangong Zhang & Haisong Zhang & Libin Bai & Yonggang Wu & Yongqiang Cheng & Yanmin Yang & Gang Han, 2024. "X-ray-activated polymerization expanding the frontiers of deep-tissue hydrogel formation," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Zhao Pan & Qi-Qi Fu & Mo-Han Wang & Huai-Ling Gao & Liang Dong & Pu Zhou & Dong-Dong Cheng & Ying Chen & Duo-Hong Zou & Jia-Cai He & Xue Feng & Shu-Hong Yu, 2023. "Designing nanohesives for rapid, universal, and robust hydrogel adhesion," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Yujie Hua & Kai Wang & Yingying Huo & Yaping Zhuang & Yuhui Wang & Wenzhuo Fang & Yuyan Sun & Guangdong Zhou & Qiang Fu & Wenguo Cui & Kaile Zhang, 2023. "Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Ying Zhang & Shenqiang Wang & Yinxian Yang & Sheng Zhao & Jiahuan You & Junxia Wang & Jingwei Cai & Hao Wang & Jie Wang & Wei Zhang & Jicheng Yu & Chunmao Han & Yuqi Zhang & Zhen Gu, 2023. "Scarless wound healing programmed by core-shell microneedles," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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